Document Detail


Tuberculosis diagnosis after bleach processing for early stage tuberculosis laboratory capacity building [Short communication].
MedLine Citation:
PMID:  23044448     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The diagnosis of tuberculosis is seriously hampered in the absence of standard biosafety laboratory facilities for specimen concentration and Mycobacterium tuberculosis culture. Within a laboratory twinning arrangement, heat-fixed direct smear and sediment from 74 bleach-processed and 20 non-processed specimens from Cumura Hospital, Guinea-Bissau, were sent to Lisbon for molecular evaluation of rifampicin resistance. Sequence analysis of a 369 base-pair rpoB locus detected 3.2% (3/94) resistant specimens. To our knowledge, this represents the first report on the molecular analysis of M. tuberculosis from bleach-processed sputum, an alternative to current diagnostic practice in low-resource settings.
Authors:
S David; A F Sutre; A Sanca; A Mané; V Henriques; C Portugal; L Sancho; A Cardoso; E Paixão; E L Duarte; C Q F Leite; J I Salem; A Antunes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease     Volume:  16     ISSN:  1815-7920     ISO Abbreviation:  Int. J. Tuberc. Lung Dis.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706389     Medline TA:  Int J Tuberc Lung Dis     Country:  France    
Other Details:
Languages:  eng     Pagination:  1535-7     Citation Subset:  IM    
Affiliation:
Instituto Nacional de Saúde Dr. Ricardo Jorge (INSA, IP), Lisbon, Portugal.
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