Document Detail


Tuberculosis diagnosed during pregnancy: a prospective study from London.
MedLine Citation:
PMID:  10639530     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A study was undertaken to characterise the presentation of tuberculosis in pregnancy and the difficulties in diagnosis in an area of the UK with a high incidence of tuberculosis. METHODS: A prospective case series was investigated at Northwick Park Hospital, a university affiliated district general hospital in Brent and Harrow health authority in north-west London which incorporates a regional infectious diseases unit. Patients diagnosed with tuberculosis over the study period were included if the onset of symptoms occurred during pregnancy. RESULTS: Thirteen patients were diagnosed during a 30 month period from December 1995 to May 1998 during which 9069 mothers were delivered, a prevalence of 143.3/100 000 deliveries. Symptoms began at a median of 22 weeks gestation (range 9-40 weeks). All patients were recent immigrants of Indian subcontinent or Somali origin and their median duration of residence in the UK was 31 months (range 1-72). Prevalence broken down for racial origin of mothers was 466.3/100 000 for mothers of black African origin and 239.1/100 000 for mothers of Indian origin. Nine of the 13 patients had extrapulmonary tuberculosis. Four patients with widely disseminated disease had a negative Mantoux response and five with localised disease had a strongly positive Mantoux response. HIV co-infection was absent. The median delay between the onset of symptoms and diagnosis was seven weeks (range 2-30). The response to standard treatment was excellent and all patients were cured. CONCLUSIONS: Tuberculosis occurring in pregnancy is common in recent immigrants. Diagnosis during pregnancy is delayed because the disease is frequently extrapulmonary with few symptoms.
Authors:
M Llewelyn; I Cropley; R J Wilkinson; R N Davidson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thorax     Volume:  55     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-02-25     Completed Date:  2000-02-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  129-32     Citation Subset:  IM; X    
Affiliation:
Wellcome Centre for Clinical Tropical Medicine, Imperial College School of Medicine, Northwick Park Hospital, Harrow HA1 3UJ, UK.
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MeSH Terms
Descriptor/Qualifier:
Antitubercular Agents / therapeutic use
Female
Humans
India / ethnology
London / epidemiology
Pregnancy
Pregnancy Complications, Infectious / diagnosis*,  drug therapy,  epidemiology
Pregnancy Outcome
Prenatal Diagnosis
Prevalence
Prospective Studies
Somalia / ethnology
Treatment Outcome
Tuberculosis / diagnosis*,  drug therapy,  epidemiology
Chemical
Reg. No./Substance:
0/Antitubercular Agents
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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