Document Detail

Tryptophol induces death receptor (DR) 5-mediated apoptosis in U937 cells.
MedLine Citation:
PMID:  17690453     Owner:  NLM     Status:  MEDLINE    
Tryptophol is a natural component isolated from vinegar produced from the boiled extract of black soybean. We have reported that tryptophol induces apoptosis in U937 cells via activation of caspase-8 followed by caspase-3. Tryptophol, however, did not affect human peripheral blood lymphocytes (PBL). In this study, we found that tryptophol enhances formation of a death-inducing signaling complex including death receptor (DR) 5. Cell viability and induction of apoptosis by tryptophol was reduced by transfection with decoy receptor (DcR) 1. These results indicate that tryptophol induces apoptosis through DR5 and that the resistance of PBL to tryptophol-induced apoptosis might be due to competition from DcR1.
Shyuichiro Inagaki; Shigeru Morimura; Yueqin Tang; Hiroshi Akutagawa; Kenji Kida
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Publication Detail:
Type:  Journal Article     Date:  2007-08-07
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  71     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-27     Completed Date:  2007-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2065-8     Citation Subset:  IM    
Graduate School of Science and Technology, Department of Materials and Life Science, Kumamoto University, Kurokami, Kumamoto, Japan.
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MeSH Terms
Apoptosis / drug effects*
Caspase 3 / metabolism
Caspase 8 / metabolism
Indoles / pharmacology*
Lymphocytes / drug effects
Receptors, TNF-Related Apoptosis-Inducing Ligand / drug effects,  physiology*
Tumor Necrosis Factor Decoy Receptors / physiology
U937 Cells
Reg. No./Substance:
0/Indoles; 0/Receptors, TNF-Related Apoptosis-Inducing Ligand; 0/TNFRSF10C protein, human; 0/Tumor Necrosis Factor Decoy Receptors; 526-55-6/tryptophol; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspase 8

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