| Tryptophan and tyrosine availability and response to antidepressant treatment in major depression. | |
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MedLine Citation:
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PMID: 15935231 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It has been suggested that the ratio of tryptophan (TRP) and tyrosine (TYR) to other large neutral amino acids may predict response to antidepressant drugs with predominantly serotonergic compared with predominantly noradrenergic activity and that this may be clinically useful. METHOD: 147 subjects with a DSM-III-R diagnosis of major depression underwent a detailed clinical evaluation and prior to treatment had baseline measures of TRP, TYR and other large neutral amino acids (LNAA), prolactin and cortisol. Subjects entered a 6-week randomised treatment trial comparing fluoxetine and nortriptyline. RESULTS: There was no main effect on 6-week outcome of TRP/LNAA ratio or TYR/LNAA ratio and no interaction between these factors and treatment (fluoxetine vs nortriptyline). LIMITATIONS: Alterations in antidepressant dose were allowed therefore possibly reducing the effect of TRP or TYR availability on response. CONCLUSIONS: Previous findings that TRP/LNAA and TYR/LNAA ratios may predict differential response to antidepressants were not replicated and neither was our previous finding of a complex relationship between TRP/LNAA and baseline prolactin in predicting 6-week response. |
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Authors:
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Richard J Porter; Roger T Mulder; Peter R Joyce; Suzanne E Luty |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of affective disorders Volume: 86 ISSN: 0165-0327 ISO Abbreviation: J Affect Disord Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-06-06 Completed Date: 2005-09-23 Revised Date: 2009-09-28 |
Medline Journal Info:
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Nlm Unique ID: 7906073 Medline TA: J Affect Disord Country: Netherlands |
Other Details:
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Languages: eng Pagination: 129-34 Citation Subset: IM |
Affiliation:
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Department of Psychological Medicine, Christchurch School of Medicine & Health Sciences, P.O. Box 4345, Christchurch, New Zealand. richard.porter@chmeds.ac.nz |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic Uptake Inhibitors
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pharmacology,
therapeutic use* Adult Amino Acids, Neutral / blood, drug effects Antidepressive Agents, Tricyclic / pharmacology, therapeutic use Circadian Rhythm Depressive Disorder, Major / blood, drug therapy* Female Fluoxetine / pharmacology, therapeutic use* Follow-Up Studies Humans Hydrocortisone / blood, metabolism Male Nortriptyline / pharmacology, therapeutic use* Prolactin / blood Psychiatric Status Rating Scales Research Design Serotonin Uptake Inhibitors / pharmacology, therapeutic use* Treatment Outcome Tryptophan / blood*, drug effects Tyrosine / blood*, drug effects, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic Uptake Inhibitors; 0/Amino Acids, Neutral; 0/Antidepressive Agents, Tricyclic; 0/Serotonin Uptake Inhibitors; 50-23-7/Hydrocortisone; 54910-89-3/Fluoxetine; 55520-40-6/Tyrosine; 72-69-5/Nortriptyline; 73-22-3/Tryptophan; 9002-62-4/Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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