Document Detail

Tryptophan and tyrosine availability and response to antidepressant treatment in major depression.
MedLine Citation:
PMID:  15935231     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It has been suggested that the ratio of tryptophan (TRP) and tyrosine (TYR) to other large neutral amino acids may predict response to antidepressant drugs with predominantly serotonergic compared with predominantly noradrenergic activity and that this may be clinically useful. METHOD: 147 subjects with a DSM-III-R diagnosis of major depression underwent a detailed clinical evaluation and prior to treatment had baseline measures of TRP, TYR and other large neutral amino acids (LNAA), prolactin and cortisol. Subjects entered a 6-week randomised treatment trial comparing fluoxetine and nortriptyline. RESULTS: There was no main effect on 6-week outcome of TRP/LNAA ratio or TYR/LNAA ratio and no interaction between these factors and treatment (fluoxetine vs nortriptyline). LIMITATIONS: Alterations in antidepressant dose were allowed therefore possibly reducing the effect of TRP or TYR availability on response. CONCLUSIONS: Previous findings that TRP/LNAA and TYR/LNAA ratios may predict differential response to antidepressants were not replicated and neither was our previous finding of a complex relationship between TRP/LNAA and baseline prolactin in predicting 6-week response.
Richard J Porter; Roger T Mulder; Peter R Joyce; Suzanne E Luty
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of affective disorders     Volume:  86     ISSN:  0165-0327     ISO Abbreviation:  J Affect Disord     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-06     Completed Date:  2005-09-23     Revised Date:  2009-09-28    
Medline Journal Info:
Nlm Unique ID:  7906073     Medline TA:  J Affect Disord     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  129-34     Citation Subset:  IM    
Department of Psychological Medicine, Christchurch School of Medicine & Health Sciences, P.O. Box 4345, Christchurch, New Zealand.
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MeSH Terms
Adrenergic Uptake Inhibitors / pharmacology,  therapeutic use*
Amino Acids, Neutral / blood,  drug effects
Antidepressive Agents, Tricyclic / pharmacology,  therapeutic use
Circadian Rhythm
Depressive Disorder, Major / blood,  drug therapy*
Fluoxetine / pharmacology,  therapeutic use*
Follow-Up Studies
Hydrocortisone / blood,  metabolism
Nortriptyline / pharmacology,  therapeutic use*
Prolactin / blood
Psychiatric Status Rating Scales
Research Design
Serotonin Uptake Inhibitors / pharmacology,  therapeutic use*
Treatment Outcome
Tryptophan / blood*,  drug effects
Tyrosine / blood*,  drug effects,  metabolism
Reg. No./Substance:
0/Adrenergic Uptake Inhibitors; 0/Amino Acids, Neutral; 0/Antidepressive Agents, Tricyclic; 0/Serotonin Uptake Inhibitors; 50-23-7/Hydrocortisone; 54910-89-3/Fluoxetine; 55520-40-6/Tyrosine; 72-69-5/Nortriptyline; 73-22-3/Tryptophan; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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