Document Detail

Tryptophan supplementation for nocturnal bruxism: report of negative results.
MedLine Citation:
PMID:  1812137     Owner:  NLM     Status:  MEDLINE    
This experiment was designed to study the effect of L-tryptophan on nocturnal bruxism. Portable EMG recorders were used to monitor unilateral masseter muscle activity during sleep in eight patients identified as nocturnal bruxists. Following an initial baseline period, the patients were given, in a randomized double-blind study, either tryptophan (50 mg/kg of body weight) or a placebo for 8 days followed by an additional 8 days of reverse medication. Dietary patterns and food intake were monitored throughout the experimental period. No significant treatment differences in bruxing levels were found, suggesting that L-tryptophan supplementation in the absence of dietary manipulation is ineffective in the treatment of nocturnal bruxism.
K R Etzel; J W Stockstill; J D Rugh; J G Fisher
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of craniomandibular disorders : facial & oral pain     Volume:  5     ISSN:  0890-2739     ISO Abbreviation:  J Craniomandib Disord     Publication Date:  1991  
Date Detail:
Created Date:  1992-06-10     Completed Date:  1992-06-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8709733     Medline TA:  J Craniomandib Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  115-20     Citation Subset:  D    
Department of Microbiology-biochemistry, University of Pittsburgh, School of Dental Medicine 15261.
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MeSH Terms
Bruxism / drug therapy*
Double-Blind Method
Masseter Muscle / drug effects,  physiology
Middle Aged
Treatment Outcome
Tryptophan / pharmacology,  therapeutic use*
Reg. No./Substance:

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