Document Detail

Tryptophan released from mother's milk has antioxidant properties.
MedLine Citation:
PMID:  19730158     Owner:  NLM     Status:  MEDLINE    
Bioactive factors in human milk (HM) are crucial to the health of newborns, especially preterm infants. These compounds assist in reducing the oxidative stress that may occur as a result of combined exposure to supplemental oxygen and immature physiologic defenses. To identify the components in HM that contribute to its greater resistance to oxidative stress compared with infant formulae, enzymatic hydrolysates of HM were prepared, ultrafiltered, separated, and analyzed for antioxidant potential. The antioxidant activity [microM Trolox equivalent (TE/g)] of nondigested milk, whole digested milk, and derived ultrafiltrates were 80.4 +/- 13.3, 159.0 +/- 5.6, and 127.4 +/- 3.1, respectively. An HPLC fraction denoted as fraction 23 (5274 +/- 630 microM TE/g) was obtained and its constituents identified as tryptophan (Trp), peptides HNPI, and PLAPQA. Scavenging activity was not observed for PLAPQA, whereas moderate activity was associated with HNPI (144 +/- 10.7 microM TE/g) and very high activity to Trp (7986 +/- 468 microM TE/g). Trp addition to HM and two infant formulas significantly increased formulae antioxidant properties. Trp appeared to be a powerful free radical scavenger naturally present in HM. Its antioxidant effects and potential application in the diets of infants, particularly preterm, must be examined further.
Apollinaire Tsopmo; Bill W Diehl-Jones; Rotimi E Aluko; David D Kitts; Ingrid Elisia; James K Friel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  66     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-18     Completed Date:  2010-03-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  614-8     Citation Subset:  IM    
Chemistry Department, Carleton University, Ottawa, Ontario K1S 5B6, Canada.
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MeSH Terms
Chromatography, High Pressure Liquid
Free Radical Scavengers / chemistry,  pharmacology*
Mass Spectrometry
Milk, Human / chemistry*
Oxidative Stress / drug effects*
Tryptophan / chemistry,  pharmacology*
Reg. No./Substance:
0/Free Radical Scavengers; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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