Document Detail

Tryptophan hydroxylase polymorphism is associated with age of onset of alcoholism related behaviors.
MedLine Citation:
PMID:  16257348     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to explore the association of a tryptophan hydroxylase gene polymorphism (TPH1 A218C) with the age of alcoholism onset in a Korean population. The genotype and allele frequencies of TPH1 were investigated in 182 male hospitalized patients who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) criteria for alcohol dependence. Alcoholics with the TPH1 AA or AC genotypes had an earlier age of disease onset (median age of onset, 26.5 years) than those with the CC genotype (median age of onset, 30 years; p=.002). Age of onset has been used in classifying alcoholics. The TPH1 polymorphism may explain, in part, the biological basis for these typologies.
In-Won Chung; Heon Kim; William Sribney; Joo-Bong Hong; Chul-Ho Lee; Kyu-Young Lee; Hong-Mei Nan; Yong-Sik Kim; Paul Manowitz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Alcohol (Fayetteville, N.Y.)     Volume:  36     ISSN:  0741-8329     ISO Abbreviation:  Alcohol     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-10-31     Completed Date:  2005-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502311     Medline TA:  Alcohol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-3     Citation Subset:  IM    
Department of Neuropsychiatry, Dongguk University International Hospital, Gyeonggi, Republic of Korea.
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MeSH Terms
Age of Onset
Alcoholism / genetics*,  psychology
Middle Aged
Polymorphism, Genetic*
Smoking / genetics
Tryptophan Hydroxylase / genetics*
Reg. No./Substance:
EC Hydroxylase

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