| Tryptophan PET in pretreatment delineation of newly-diagnosed gliomas: MRI and histopathologic correlates. | |
| | |
MedLine Citation:
|
PMID: 23299463 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Pretreatment delineation of infiltrating glioma volume remains suboptimal with current neuroimaging techniques. Gadolinium-enhanced T1-weighted (T1-Gad) MR images often underestimate the true extent of the tumor, while T2-weighted images preferentially highlight peritumoral edema. Accumulation of α-[(11)C]methyl-L-tryptophan (AMT) on positron emission tomography (PET) has been shown in gliomas. To determine whether increased uptake on AMT-PET would detect tumor-infiltrated brain tissue outside the contrast-enhancing region and differentiate it from peritumoral vasogenic edema, volumes and spatial concordance of T1-Gad and T2 MRI abnormalities as well as AMT-PET abnormalities were analyzed in 28 patients with newly-diagnosed WHO grade II-IV gliomas. AMT-accumulating grade I meningiomas were used to define an AMT uptake cutoff threshold that detects the tumor but excludes peri-meningioma vasogenic edema. Tumor infiltration in AMT-accumulating areas was studied in stereotactically-resected specimens from patients with glioblastoma. In the 28 gliomas, mean AMT-PET-defined tumor volumes were greater than the contrast-enhancing volume, but smaller than T2 abnormalities. Volume of AMT-accumulating tissue outside MRI abnormalities increased with higher tumor proliferative index and was the largest in glioblastomas. Tumor infiltration was confirmed by histopathology from AMT-positive regions outside contrast-enhancing glioblastoma mass, while no or minimal tumor cells were found in AMT-negative specimens. These results demonstrate that increased AMT accumulation on PET detects glioma-infiltrated brain tissue extending beyond the contrast-enhanced tumor mass. While tryptophan uptake is low in peritumoral vasogenic edema, AMT-PET can detect tumor-infiltrated brain outside T2-lesions. Thus, AMT-PET may assist pretreatment delineation of tumor infiltration, particularly in high-grade gliomas. |
| | |
Authors:
|
David O Kamson; Csaba Juhász; Amy Buth; William J Kupsky; Geoffrey R Barger; Pulak K Chakraborty; Otto Muzik; Sandeep Mittal |
Related Documents
:
|
23287703 - Infiltration of the optic chiasm, nerve, and disc by gliomatosis cerebri. 20306263 - Ultrasound-guided intratumoral administration of collagenase-2 improved liposome drug a... 16952843 - Molecular biology in acute leukemia. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-9 |
Journal Detail:
|
Title: Journal of neuro-oncology Volume: - ISSN: 1573-7373 ISO Abbreviation: J. Neurooncol. Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-9 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8309335 Medline TA: J Neurooncol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
PET Center and Translational Imaging Laboratory, Children's Hospital of Michigan, Detroit, MI, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: MicroRNA-107 inhibits glioma cell migration and invasion by modulating Notch2 expression.
Next Document: "One week on-one week off": efficacy and side effects of dose-intensified temozolomide chemotherapy:...