Document Detail


Tryptic hydrolysis of omega-amidino alpha-amino acid (indospecine) esters.
MedLine Citation:
PMID:  7390986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several esters of a series of omega-amidino alpha-amino acids were synthesized. Some of them were shown to be efficiently hydrolyzed by bovine trypsin [EC 3.4.21.4]. The kinetics of hydrolysis of the esters were compared with those of the omega-guanidino series. The relationships between the length of the side chain and the susceptibility to hydrolysis by trypsin were somewhat different in the two series. These slight differences are discussed in terms of the molecular structures and their relation to the structural requirements of the trypsin active site.
Authors:
T Fujioka; T Satoh; K Tanizawa; Y Kanaoka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biochemistry     Volume:  87     ISSN:  0021-924X     ISO Abbreviation:  J. Biochem.     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-09-23     Completed Date:  1980-09-23     Revised Date:  2007-12-19    
Medline Journal Info:
Nlm Unique ID:  0376600     Medline TA:  J Biochem     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1229-34     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acids, Diamino*
Kinetics
Structure-Activity Relationship
Substrate Specificity
Trypsin / metabolism*
Chemical
Reg. No./Substance:
0/Amino Acids, Diamino; EC 3.4.21.4/Trypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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