| Tryptic hydrolysis of omega-amidino alpha-amino acid (indospecine) esters. | |
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MedLine Citation:
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PMID: 7390986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several esters of a series of omega-amidino alpha-amino acids were synthesized. Some of them were shown to be efficiently hydrolyzed by bovine trypsin [EC 3.4.21.4]. The kinetics of hydrolysis of the esters were compared with those of the omega-guanidino series. The relationships between the length of the side chain and the susceptibility to hydrolysis by trypsin were somewhat different in the two series. These slight differences are discussed in terms of the molecular structures and their relation to the structural requirements of the trypsin active site. |
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Authors:
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T Fujioka; T Satoh; K Tanizawa; Y Kanaoka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of biochemistry Volume: 87 ISSN: 0021-924X ISO Abbreviation: J. Biochem. Publication Date: 1980 Apr |
Date Detail:
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Created Date: 1980-09-23 Completed Date: 1980-09-23 Revised Date: 2007-12-19 |
Medline Journal Info:
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Nlm Unique ID: 0376600 Medline TA: J Biochem Country: JAPAN |
Other Details:
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Languages: eng Pagination: 1229-34 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids, Diamino* Kinetics Structure-Activity Relationship Substrate Specificity Trypsin / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids, Diamino; EC 3.4.21.4/Trypsin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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