Document Detail

Tryptamine receptors in rat pulmonary artery.
MedLine Citation:
PMID:  4451759     Owner:  NLM     Status:  MEDLINE    
Tryptamine and 5-hydroxytryptamine (5-HT) are equipotent in contracting spiral strips of rat isolated pulmonary artery, in doses between 5 and 20 mug. These 5-HT receptors are blocked by low concentrations (c. 10(-9) M) of both methysergide and morphine. In rat isolated lung perfused via the pulmonary circulation, 5-HT caused increases in perfusion pressure which were also antagonized by methysergide and by morphine. These vascular 5-HT receptors cannot therefore be classified as M or D receptors and, furthermore, are different from those 5-HT receptors mediating release of spasmogens from rat isolated lungs.
Y S Bakhle; T W Smith
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  51     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1974 Jul 
Date Detail:
Created Date:  1975-06-12     Completed Date:  1975-06-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  459-61     Citation Subset:  IM    
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MeSH Terms
Dose-Response Relationship, Drug
Methysergide / pharmacology
Morphine / pharmacology
Muscle Contraction / drug effects
Pulmonary Artery / drug effects*
Receptors, Drug*
Serotonin / pharmacology
Tryptamines* / pharmacology
Reg. No./Substance:
0/Receptors, Drug; 0/Tryptamines; 361-37-5/Methysergide; 50-67-9/Serotonin; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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