| Tryptamine receptors in rat pulmonary artery. | |
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MedLine Citation:
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PMID: 4451759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tryptamine and 5-hydroxytryptamine (5-HT) are equipotent in contracting spiral strips of rat isolated pulmonary artery, in doses between 5 and 20 mug. These 5-HT receptors are blocked by low concentrations (c. 10(-9) M) of both methysergide and morphine. In rat isolated lung perfused via the pulmonary circulation, 5-HT caused increases in perfusion pressure which were also antagonized by methysergide and by morphine. These vascular 5-HT receptors cannot therefore be classified as M or D receptors and, furthermore, are different from those 5-HT receptors mediating release of spasmogens from rat isolated lungs. |
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Authors:
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Y S Bakhle; T W Smith |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: British journal of pharmacology Volume: 51 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1974 Jul |
Date Detail:
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Created Date: 1975-06-12 Completed Date: 1975-06-12 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 459-61 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dose-Response Relationship, Drug Female Lung Male Methysergide / pharmacology Morphine / pharmacology Muscle Contraction / drug effects Perfusion Pulmonary Artery / drug effects* Rats Receptors, Drug* Serotonin / pharmacology Tryptamines* / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Drug; 0/Tryptamines; 361-37-5/Methysergide; 50-67-9/Serotonin; 57-27-2/Morphine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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