Document Detail


Trypsin-like activity and thromboxane release in adult respiratory distress syndrome.
MedLine Citation:
PMID:  3532205     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasmatic immunoreactive trypsin (IRT), thromboxane and trypsin-like enzymatic activity were measured in 117 patients at risk of developing adult respiratory distress syndrome (ARDS) (53 multiple injury, 30 abdominal surgery, 17 acute pancreatitis, 12 burnt and 5 disseminated intravascular coagulation patients). 69 of these patients developed ARDS. Immunoreactive trypsin and thromboxane were measured by radio-immuno-assay and trypsin-like enzymatic activity by spectrophotometry, using a specific chromogenic substrate. Mean IRT value was 675 ng/ml in ARDS and 265 ng/ml in non ARDS patients (p less than 0.05). Mean IRT value was 685 ng/ml in septic and 170 ng/ml in non septic patients (p less than 0.01). An abnormal trypsin-like enzymatic activity was measured in 26 ARDS patients. In 60 patients (37 ARDS and 23 non ARDS), thromboxane appeared in plasma simultaneously or about 24 hours after the beginning of IRT release. The importance of thromboxane release parallels the intensity of IRT. Originating from pancreas, trypsin can appear in plasma either by absorption from gastrointestinal tract or after pancreatic ischemia.
Authors:
G Deby-Dupont; J Pincemail; M E Faymonville; M Braun; C Deby; R Goutier; M Lamy; P Franchimont
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prostaglandins     Volume:  32     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-11-21     Completed Date:  1986-11-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  106-10     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Clinical Enzyme Tests
Humans
Laboratory Techniques and Procedures
Peptide Hydrolases / blood*
Radioimmunoassay / methods
Respiratory Distress Syndrome, Adult / blood*,  diagnosis,  enzymology
Risk
Spectrophotometry / methods
Thromboxanes / blood*
Trypsin / blood*
Chemical
Reg. No./Substance:
0/Thromboxanes; EC 3.4.-/Peptide Hydrolases; EC 3.4.21.4/Trypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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