Document Detail


Trypsin inhibitor effects on food intake and weight gain in Zucker rats.
MedLine Citation:
PMID:  6657770     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Decreased body weight and increased pancreas weight which occur in rats fed raw soybeans are thought to be due to the presence of trypsin inhibitors in the soybeans (SBTI). Since trypsin is postulated to be a negative feedback signal for cholecystokinin (CCK) secretion, SBTI may have these effects by increasing secretion of CCK. CCK is a putative satiety signal; thus, increased secretion of CCK could decrease food intake, and, if maintained over a period of time, body weight. In these experiments the effects of a trypsin inhibitor [N,N-dimethyl-carbamoyl 4-(4-guanidino-benzylyloxy)-phenyl acetate methane-sulfate (DGPM)]on feeding pattern were investigated in Zucker obese and lean rats. Administration of 25-200 mg/kg DGPM to 6-hr fasted rats decreased daily food intake by dose-dependently decreasing average meal size in both obese and lean rats, but the response was greater in obese rats. Administration of 100 mg/kg DGPM twice daily for 7 days decreased food intake and body weight in obese but not lean rats. Thus, these results suggest that decreased body weight associated with SBTI is due to decreased food intake partly as a result of increased secretion of the putative satiety peptide CCK.
Authors:
C L McLaughlin; S R Peikin; C A Baile
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  31     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1984-02-14     Completed Date:  1984-02-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  487-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects*
Cholecystokinin / physiology
Eating / drug effects*
Female
Guanidines / pharmacology
Male
Rats
Rats, Zucker
Satiation / drug effects
Time Factors
Trypsin Inhibitors / pharmacology*
Grant Support
ID/Acronym/Agency:
S07-RR-05464/RR/NCRR NIH HHS; S07-RR-07083/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Guanidines; 0/Trypsin Inhibitors; 88025-93-8/N,N-dimethylcarbamoyl-4-(4-guanidinobenzyloxy)phenyl acetate methane sulfate; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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