| Trypanosome hydrolases and the blood-brain barrier. | |
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MedLine Citation:
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PMID: 11850009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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African trypanosomes cross the blood-brain barrier, but how they do so remains an area of speculation. We propose that proteases, such as the trypanopains and oligopeptidases that are released by trypanosomes, could mediate in this process. The trypanosomes also possess cell-surface-associated acid phosphatases that could play a role in invasion similar to that in advancing cancer cells. Such enzymes, perhaps acting in concert, have the potential to cause tissue degradation and ease the passage of the trypanosomes through various tissues in the host, including the blood-brain barrier. |
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Authors:
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John D Lonsdale-Eccles; Dennis J Grab |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Trends in parasitology Volume: 18 ISSN: 1471-4922 ISO Abbreviation: Trends Parasitol. Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2002-02-18 Completed Date: 2002-04-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100966034 Medline TA: Trends Parasitol Country: England |
Other Details:
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Languages: eng Pagination: 17-9 Citation Subset: IM |
Affiliation:
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Center for Biophysical Sciences and Engineering, University of Alabama, Birmingham, AL 35294, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport / physiology Blood-Brain Barrier Brain / parasitology* Cattle Central Nervous System / parasitology Endopeptidases / metabolism* Humans Hydrolases / metabolism* Models, Biological Rats Trypanosoma / enzymology* Trypanosomiasis, African / complications, physiopathology |
| Chemical | |
Reg. No./Substance:
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EC 3.-/Hydrolases; EC 3.4.-/Endopeptidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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