Document Detail

Trypanosome hydrolases and the blood-brain barrier.
MedLine Citation:
PMID:  11850009     Owner:  NLM     Status:  MEDLINE    
African trypanosomes cross the blood-brain barrier, but how they do so remains an area of speculation. We propose that proteases, such as the trypanopains and oligopeptidases that are released by trypanosomes, could mediate in this process. The trypanosomes also possess cell-surface-associated acid phosphatases that could play a role in invasion similar to that in advancing cancer cells. Such enzymes, perhaps acting in concert, have the potential to cause tissue degradation and ease the passage of the trypanosomes through various tissues in the host, including the blood-brain barrier.
John D Lonsdale-Eccles; Dennis J Grab
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Trends in parasitology     Volume:  18     ISSN:  1471-4922     ISO Abbreviation:  Trends Parasitol.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-02-18     Completed Date:  2002-04-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100966034     Medline TA:  Trends Parasitol     Country:  England    
Other Details:
Languages:  eng     Pagination:  17-9     Citation Subset:  IM    
Center for Biophysical Sciences and Engineering, University of Alabama, Birmingham, AL 35294, USA.
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MeSH Terms
Biological Transport / physiology
Blood-Brain Barrier
Brain / parasitology*
Central Nervous System / parasitology
Endopeptidases / metabolism*
Hydrolases / metabolism*
Models, Biological
Trypanosoma / enzymology*
Trypanosomiasis, African / complications,  physiopathology
Reg. No./Substance:
EC 3.-/Hydrolases; EC 3.4.-/Endopeptidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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