| Trypanosoma musculi infections in normocomplementemic, C5-deficient, and C3-depleted mice. | |
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MedLine Citation:
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PMID: 863515 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of complement in host resistance to infection with Trypanosoma musculi was studied in normal, C5-deficient, and C3-depleted mice. Infections in normocomplementemic strains (CBA and B10.D2/n) were generally similar to those in strains genetically deficient in C5 (A and B10.D2/o). There were no differences in inhibition of reproduction, duration of infection, persistence of parasites in the kidneys, or resistance to reinfection. However, peak parasitemias in B10.D2/o mice were slightly greater than in B10.D2/n mice. In addition, B10.D2/o mice had slightly decreased serum levels of C1 early in the course of infection and of C3 early during the elimination of adult forms. These components were unchanged or increased in infections of B10.D2/n. Depletion of C3 and late-acting components in B10.D2/n mice by treatment with cobra venom factor during the reproductive stage of infection resulted in an increase of reproductive forms before the apparent development of ablastic immunity as well as slightly greater peak parasitemias when compared with those of untreated controls. Cobra venom factor treatment of B10.D2/o mice during the reproductive stage did not alter the course of infection. Cobra venom factor treatment of C3H mice during the adult stage prolonged infections by interfering with parasite elimination. It is concluded that complement-mediated lysis is not involved in control of T. musculi. It is not clear whether a C3-dependent function such as phagocytosis may facilitate elimination of the parasites. The major difference in degree of parasitemias among the various strains of mice studied is due to genetic factors rather than the levels of C3, C5, or late-acting complement components. |
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Authors:
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J A Jarvinen; A P Dalmasso |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Infection and immunity Volume: 16 ISSN: 0019-9567 ISO Abbreviation: Infect. Immun. Publication Date: 1977 May |
Date Detail:
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Created Date: 1977-07-29 Completed Date: 1977-07-29 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0246127 Medline TA: Infect Immun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 557-63 Citation Subset: IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Complement C3 / metabolism* Complement C5 / deficiency* Complement System Proteins / deficiency*, metabolism* Kidney / parasitology Male Mice Mice, Inbred A Mice, Inbred C3H Mice, Inbred CBA Snake Venoms / pharmacology Trypanosoma / immunology* Trypanosomiasis / immunology*, parasitology |
| Chemical | |
Reg. No./Substance:
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0/Complement C3; 0/Complement C5; 0/Snake Venoms; 9007-36-7/Complement System Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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