| Trypanosoma cruzi suppresses the expression of the p75 chain of interleukin-2 receptors on the surface of activated helper and cytotoxic human lymphocytes. | |
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MedLine Citation:
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PMID: 1533390 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When Trypanosoma cruzi is co-cultured with activated human lymphocytes the latter manifest a marked level of suppression in their capacity to express high-affinity interleukin-2 receptors (IL-2R). In this study we asked whether this effect could result from reduced expression of the p75 component of the IL-2R, a condition which would limit the number of heterodimeric receptors that could be assembled by activated T cells. The results of two-colour flow cytometric analyses revealed that both the percentage and surface density of p75 molecules on phytohaemagglutinin-stimulated CD3+, CD4+ or CD8+ lymphocytes were significantly reduced in the presence of T. cruzi, whether or not the parasites were separated from the lymphocytes by a cell-impermeable filter. These results suggested that reduced expression of p75 chains would limit the number of IL-2R assembled by activated T lymphocytes, contributing in this manner to the immunosuppression that occurs during acute T. cruzi infection. |
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Authors:
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F Kierszenbaum; M B Sztein |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Immunology Volume: 75 ISSN: 0019-2805 ISO Abbreviation: Immunology Publication Date: 1992 Mar |
Date Detail:
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Created Date: 1992-06-01 Completed Date: 1992-06-01 Revised Date: 2010-09-07 |
Medline Journal Info:
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Nlm Unique ID: 0374672 Medline TA: Immunology Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 546-9 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Public Health, Michigan State University, East Lansing 48824. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD
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analysis Chagas Disease / immunology* Humans Immune Tolerance / immunology* Lymphocyte Activation / immunology Receptors, Interleukin-2 / analysis* T-Lymphocytes, Cytotoxic / immunology* T-Lymphocytes, Helper-Inducer / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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AI-26542/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Receptors, Interleukin-2 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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