| Trypanosoma cruzi: the role of PGE2 in immune response during the acute phase of experimental infection. | |
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MedLine Citation:
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PMID: 18163990 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chagas disease is characterized by cardiac lesions and a high level of PGE2. Our objective was to investigate the role of PGE2 in cardiac lesions. BALB/c mice were infected with Trypanosoma cruzi (1x10(3) trypomastigote forms) and were treated daily with PBS, meloxicam (0.5 mg/kg) or etoricoxib (0.6 mg/kg). The animals were sacrificed on the 21st day of infection and we collected the cardiac tissue and spleen cells for tissue culture. We observed that treatment with COX-2 inhibitors was able to decrease synthesis of PGE2 by spleen cells. This reduction was accompanied by reduction of the inflammatory infiltrate, parasite nets, cardiac fibrosis and fewer COX-2 positive cells in cardiac tissue obtained from these animals. In conclusion, treatment with COX-2 inhibitors, and consequent inhibition of PGE2 synthesis, was able to reduce the cardiac damage observed during the acute phase of experimental Chagas disease, thus demonstrating the involvement of this mediator in the cardiac lesion. |
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Authors:
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G K Abdalla; G E L Faria; K T Silva; E C C Castro; M A Reis; M A Michelin |
Publication Detail:
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Type: Journal Article Date: 2007-11-17 |
Journal Detail:
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Title: Experimental parasitology Volume: 118 ISSN: 0014-4894 ISO Abbreviation: Exp. Parasitol. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-17 Completed Date: 2008-05-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370713 Medline TA: Exp Parasitol Country: United States |
Other Details:
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Languages: eng Pagination: 514-21 Citation Subset: IM |
Affiliation:
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Laboratory of Immunology, Federal University of Triângulo Mineiro, Rua Frei Paulino, 30, 38 025-180 Uberaba, MG, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Cells, Cultured Chagas Disease / drug therapy, immunology*, pathology Cyclooxygenase 1 / analysis Cyclooxygenase 2 / analysis Cyclooxygenase Inhibitors / therapeutic use Dinoprostone / biosynthesis, physiology* Fibrosis Male Mice Mice, Inbred BALB C Myocardium / enzymology, pathology Parasitemia / drug therapy, parasitology Prostaglandins / analysis Pyridines / therapeutic use Spleen / chemistry, cytology Sulfones / therapeutic use Thiazines / therapeutic use Thiazoles / therapeutic use Trypanosoma cruzi / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Cyclooxygenase Inhibitors; 0/Prostaglandins; 0/Pyridines; 0/Sulfones; 0/Thiazines; 0/Thiazoles; 202409-33-4/etoricoxib; 363-24-6/Dinoprostone; 71125-38-7/meloxicam; EC 1.14.99.1/Cyclooxygenase 1; EC 1.14.99.1/Cyclooxygenase 2 |
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