| Trypanosoma cruzi DNA in cardiac lesions of Argentinean patients with end-stage chronic chagas heart disease. | |
| | |
MedLine Citation:
|
PMID: 14993635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The extent of inflammation, fibrosis, and progression of chronic Chagas heart disease (cChHD) was associated with persistence of parasite DNA in cardiac lesions of necropsies or explants from Argentinean cChHD patients. A Trypanosoma cruzi-based polymerase chain reaction showed a positive result in 1) 15% of cardiac sections with less than 10 mononuclear inflammatory cells/high-power field (440x) (MNC/HPF), 89% with 10-19 MNC/HPF, and 100% with more than 20 MNC/HPF (P < 0.0001); 2) 33% with less than 10% fibrosis, 79% with 10-19% fibrosis, and 100% with more than 20% fibrosis (P < 0.01); 3) 25% of specimens from patients classified in Kuschnir groups 0 and I, 70% in group II and 90% in group III (P < .001); and 4) 45% and 90% of the specimens from cChHD patients without or with heart failure, respectively (P < 0.01). These findings stress the role of the parasite in pathogenesis and disease progression of cChHD. |
| | |
Authors:
|
Alejandro G Schijman; Carlos A Vigliano; Rodolfo J Viotti; Juan M Burgos; Silvia Brandariz; Bruno E Lococo; Maria I Leze; Hector A Armenti; Mariano J Levin |
Related Documents
:
|
9209945 - Acute staphylococcal myocarditis masquerading as an acute myocardial infarction. 7774305 - Role of myocarditis in athletes with minor arrhythmias and/or echocardiographic abnorma... 20714885 - Noninvasive diagnosis of cardiac amyloidosis by mri and echochardiography. 23102035 - Electrocardiographic patterns mimicking st segment elevation myocardial infarction. 983795 - Extreme elevation of transaminase levels in acute heart disease-a problem in differenti... 3706355 - Silent myocardial ischemia: dimensions of the problem in patients with and without angina. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The American journal of tropical medicine and hygiene Volume: 70 ISSN: 0002-9637 ISO Abbreviation: Am. J. Trop. Med. Hyg. Publication Date: 2004 Feb |
Date Detail:
|
Created Date: 2004-03-04 Completed Date: 2004-03-09 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: United States |
Other Details:
|
Languages: eng Pagination: 210-20 Citation Subset: AIM; IM |
Affiliation:
|
Laboratorio de Biología Molecular de la Enfermedad de Chagas, INGEBI, Consejo Nacional de Ciencia y Tecnologia, Department of Fisiology, Celular and Molecular Biology, F. CEyN, University of Buenos Aires, Buenos Aires, Argentina. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Animals Argentina Base Sequence Blotting, Southern Chagas Cardiomyopathy / mortality, parasitology*, pathology Chronic Disease DNA, Protozoan / chemistry, isolation & purification* Electrophoresis, Agar Gel Female Fibrosis Heart / parasitology* Humans Inflammation Male Middle Aged Molecular Sequence Data Myocardium / pathology* Polymerase Chain Reaction Trypanosoma cruzi / genetics, isolation & purification* |
| Chemical | |
Reg. No./Substance:
|
0/DNA, Protozoan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Maternal Trypanosoma cruzi infection, pregnancy outcome, morbidity, and mortality of congenitally in...
Next Document: Determination of the prevalence of Entamoeba histolytica and E. dispar in the pernambuco state of no...