Document Detail


Trypanosoma cruzi DNA in cardiac lesions of Argentinean patients with end-stage chronic chagas heart disease.
MedLine Citation:
PMID:  14993635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The extent of inflammation, fibrosis, and progression of chronic Chagas heart disease (cChHD) was associated with persistence of parasite DNA in cardiac lesions of necropsies or explants from Argentinean cChHD patients. A Trypanosoma cruzi-based polymerase chain reaction showed a positive result in 1) 15% of cardiac sections with less than 10 mononuclear inflammatory cells/high-power field (440x) (MNC/HPF), 89% with 10-19 MNC/HPF, and 100% with more than 20 MNC/HPF (P < 0.0001); 2) 33% with less than 10% fibrosis, 79% with 10-19% fibrosis, and 100% with more than 20% fibrosis (P < 0.01); 3) 25% of specimens from patients classified in Kuschnir groups 0 and I, 70% in group II and 90% in group III (P < .001); and 4) 45% and 90% of the specimens from cChHD patients without or with heart failure, respectively (P < 0.01). These findings stress the role of the parasite in pathogenesis and disease progression of cChHD.
Authors:
Alejandro G Schijman; Carlos A Vigliano; Rodolfo J Viotti; Juan M Burgos; Silvia Brandariz; Bruno E Lococo; Maria I Leze; Hector A Armenti; Mariano J Levin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  70     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-03-04     Completed Date:  2004-03-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  210-20     Citation Subset:  AIM; IM    
Affiliation:
Laboratorio de Biología Molecular de la Enfermedad de Chagas, INGEBI, Consejo Nacional de Ciencia y Tecnologia, Department of Fisiology, Celular and Molecular Biology, F. CEyN, University of Buenos Aires, Buenos Aires, Argentina.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Animals
Argentina
Base Sequence
Blotting, Southern
Chagas Cardiomyopathy / mortality,  parasitology*,  pathology
Chronic Disease
DNA, Protozoan / chemistry,  isolation & purification*
Electrophoresis, Agar Gel
Female
Fibrosis
Heart / parasitology*
Humans
Inflammation
Male
Middle Aged
Molecular Sequence Data
Myocardium / pathology*
Polymerase Chain Reaction
Trypanosoma cruzi / genetics,  isolation & purification*
Chemical
Reg. No./Substance:
0/DNA, Protozoan

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