Document Detail


Trypanosoma congolense infections: MHC class II-restricted immune responses mediate either protection or disease, depending on IL-10 function.
MedLine Citation:
PMID:  17241399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BALB/c mice are highly susceptible and C57BL/6 relatively resistant to Trypanosoma congolense infections. Here we show that relatively resistant wild-type B6 mice infected with T. congolense survive significantly longer (> 200 days) than infected major histocompatibility complex (MHC) class II-deficient B6 mice (approximately 50 days). We also show that blocking of the interleukin-10 (IL-10) receptor induces early death of wild-type B6 mice infected with T. congolense (approximately 10 days), but does not affect the survival of infected MHC class II-deficient B6 mice. We conclude that MHC class II-restricted immune responses mediate protection and, when IL-10 function is impaired, MHC class II-restricted immune responses mediate early mortality in otherwise resistant B6 mice. Thus, in T. congolense infections, MHC class II-restricted immune responses mediate either protection or disease, depending on IL-10 function.
Authors:
M Q Shi; G J Wei; H Tabel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Parasite immunology     Volume:  29     ISSN:  0141-9838     ISO Abbreviation:  Parasite Immunol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-23     Completed Date:  2007-03-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910948     Medline TA:  Parasite Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  107-11     Citation Subset:  IM    
Affiliation:
Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigen Presentation
Female
Histocompatibility Antigens Class II / genetics,  immunology*,  metabolism
Interleukin-10 / immunology*,  metabolism
Mice
Trypanosoma congolense / immunology*,  pathogenicity
Trypanosomiasis, African / immunology*,  mortality*,  parasitology
Chemical
Reg. No./Substance:
0/Histocompatibility Antigens Class II; 130068-27-8/Interleukin-10

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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