| Trypanosoma brucei FKBP12 differentially controls motility and cytokinesis in procyclic and bloodstream forms. | |
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MedLine Citation:
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PMID: 23104568 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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FKBP12 proteins are able to inhibit TOR kinases or calcineurine phosphatases upon binding of rapamycin and FK506 drugs respectively. The Trypanosoma brucei homologue TbFKBP12 was found to be a cytoskeleton-associated protein with specific localization in the flagellar pocket area of the bloodstream form. In the insect procyclic form, RNA interference-mediated knockdown of TbFKBP12 affected motility. In bloodstream cells, depletion of TbFKBP12 affected cytokinesis and cytoskeleton architecture. These last effects were associated to the presence of internal translucent cavities limited by an inside-out configuration of the normal cell surface, with a luminal VSG coat lined up by microtubules. These cavities, which recreated the streamlined shape of the normal trypanosome cytoskeleton, might represent unsuccessful attempts for cell abscission. We propose that TbFKBP12 differentially affects stage-specific processes through association with the cytoskeleton. |
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Authors:
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Anaïs Brasseur; Brice Rotureau; Marjorie Vermeersch; Thierry Blisnick; Didier Salmon; Philippe Bastin; Etienne Pays; Luc Vanhamme; David Pérez-Morga |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-26 |
Journal Detail:
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Title: Eukaryotic cell Volume: - ISSN: 1535-9786 ISO Abbreviation: Eukaryotic Cell Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101130731 Medline TA: Eukaryot Cell Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Laboratory of Molecular Parasitology, IBMM, Université Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, B-6041 Gosselies (Belgium). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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