Document Detail

Trypanocidal effects of gallic acid and related compounds.
MedLine Citation:
PMID:  9491765     Owner:  NLM     Status:  MEDLINE    
Gallic acid (3,4,5-trihydroxybenzoic acid) is a naturally abundant plant phenolic compound and it is well known as a component of hydrolyzable tannins. We report here that gallic acid and related compounds have trypanocidal activity against Trypanosoma brucei brucei (GUTat 3.1) in both the long slender bloodstream forms and the procyclic forms, in vitro. LD50 values of gallic acid are 46.96 +/- 1.28 microM for bloodstream forms and 30.02 +/- 3.49 for procyclic forms, respectively. A study of structurally related compounds suggested that the pyrogallol moiety could be responsible for this activity.
T Koide; M Nose; M Inoue; Y Ogihara; Y Yabu; N Ohta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Planta medica     Volume:  64     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-26     Completed Date:  1998-03-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  27-30     Citation Subset:  IM    
Department of Pharmacognosy and Plant Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
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MeSH Terms
Gallic Acid / analogs & derivatives,  pharmacology*
Trypanocidal Agents / pharmacology*
Trypanosoma brucei brucei / drug effects*
Reg. No./Substance:
0/Trypanocidal Agents; 149-91-7/Gallic Acid

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