| Trypanocidal effects of gallic acid and related compounds. | |
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MedLine Citation:
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PMID: 9491765 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gallic acid (3,4,5-trihydroxybenzoic acid) is a naturally abundant plant phenolic compound and it is well known as a component of hydrolyzable tannins. We report here that gallic acid and related compounds have trypanocidal activity against Trypanosoma brucei brucei (GUTat 3.1) in both the long slender bloodstream forms and the procyclic forms, in vitro. LD50 values of gallic acid are 46.96 +/- 1.28 microM for bloodstream forms and 30.02 +/- 3.49 for procyclic forms, respectively. A study of structurally related compounds suggested that the pyrogallol moiety could be responsible for this activity. |
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Authors:
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T Koide; M Nose; M Inoue; Y Ogihara; Y Yabu; N Ohta |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Planta medica Volume: 64 ISSN: 0032-0943 ISO Abbreviation: Planta Med. Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-03-26 Completed Date: 1998-03-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0066751 Medline TA: Planta Med Country: GERMANY |
Other Details:
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Languages: eng Pagination: 27-30 Citation Subset: IM |
Affiliation:
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Department of Pharmacognosy and Plant Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gallic Acid / analogs & derivatives, pharmacology* Mice Trypanocidal Agents / pharmacology* Trypanosoma brucei brucei / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Trypanocidal Agents; 149-91-7/Gallic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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