Document Detail


Trypanocidal effects of curcumin in vitro.
MedLine Citation:
PMID:  9657056     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During the course of study searching for the antiparasitic agents from natural compounds, we found that curcumin showed cytotoxicity against African trypanosomes in vitro. The LD50 values of curcumin were 4.77 +/- 0.91 microM for bloodstream forms and 46.52 +/- 4.94 microM for procyclic forms of Trypanosoma brucei brucei (GUTat 3.1 clone).
Authors:
M Nose; T Koide; Y Ogihara; Y Yabu; N Ohta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  21     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-09-04     Completed Date:  1998-09-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  643-5     Citation Subset:  IM    
Affiliation:
Department of Pharmacognosy and Plant Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Curcumin / pharmacology*
Mice
Trypanocidal Agents / pharmacology*
Trypanosoma brucei brucei / drug effects*
Chemical
Reg. No./Substance:
0/Trypanocidal Agents; 458-37-7/Curcumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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