Document Detail


Trypanocidal effect of SKF525A, proadifen, on different developmental forms of Trypanosoma cruzi.
MedLine Citation:
PMID:  9816705     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
SKF525A, an inhibitor and inducer of cytochrome P450, was tested on different developmental stages of Trypanosoma cruzi. Growth, motility and structure of epimastigotes, motility and infectivity of trypomastigotes, and infectivity of trypomastigotes to Vero cells in culture were abolished by the drug at 10-100 microM concentrations. When blood from infected mice was treated with the drug, and used to infect 8 day-old mice, no parasites were observed at 0.6-1 mM, and all animals survived. Blood cell morphology was well preserved, and the sleeping time of pentobarbital-treated mice inoculated with the same amount of drug was not increased. The present results suggest that SKF525A or other related inhibitors of cytochrome P450 coned be tested as an additive for blood sterilization in blood banks.
Authors:
B M Franke De Cazzulo; A Bernacchi; M I Esteva; A M Ruiz; J A Castro; J J Cazzulo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicina     Volume:  58     ISSN:  0025-7680     ISO Abbreviation:  Medicina (B Aires)     Publication Date:  1998  
Date Detail:
Created Date:  1999-02-04     Completed Date:  1999-02-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0204271     Medline TA:  Medicina (B Aires)     Country:  ARGENTINA    
Other Details:
Languages:  eng     Pagination:  415-8     Citation Subset:  IM    
Affiliation:
Instituto de Investigaciones Biotecnológicas, Universidad Nacional de General San Martín, Argentina. jcazzulo@inti.gov.ar
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MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Cercopithecus aethiops
Cytochrome P-450 Enzyme System / drug effects
Enzyme Inhibitors / pharmacology*
Male
Mice
Mice, Inbred BALB C
Pentobarbital / pharmacology
Proadifen / pharmacology*
Time Factors
Trypanocidal Agents / pharmacology*
Trypanosoma cruzi / drug effects*,  enzymology,  ultrastructure
Vero Cells / drug effects
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Trypanocidal Agents; 302-33-0/Proadifen; 76-74-4/Pentobarbital; 9035-51-2/Cytochrome P-450 Enzyme System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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