| Truncating the dose range for methacholine challenge tests: three occupational studies. | |
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MedLine Citation:
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PMID: 12915785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The methacholine challenge test protocol was assessed in the reanalysis of three occupational studies. We evaluated the impact of truncating the range of methacholine on responsiveness, as defined by slope and PC(20). In original analysis, reactivity was similar for apprentices and auto body shop workers, whereas boilermakers were more responsive. Truncating high concentrations did not change the classification of subjects with PC(20) <8 or 16 in any population. However, when responsiveness was measured by slope, the mean responsiveness increased, from -7.9 to -15.3 for apprentices and -7.2 to -10.0 for auto-body shop workers. Results support the American Thoracic Society's recommended maximum of 16 mg/ml and provide evidence that extending the dose range beyond that does not increase sensitivity, whereas stopping before 16 may exaggerate response. Furthermore, to ensure validity, neither slope nor PC(20) should be extrapolated beyond data. |
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Authors:
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Ilir Agalliu; Ellen A Eisen; Russ Hauser; Carrie A Redlich; Meredith H Stowe; Mark R Cullen; David H Wegman; David C Christiani; Susan M Kennedy |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine Volume: 45 ISSN: 1076-2752 ISO Abbreviation: J. Occup. Environ. Med. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-08-13 Completed Date: 2003-10-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9504688 Medline TA: J Occup Environ Med Country: United States |
Other Details:
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Languages: eng Pagination: 841-7 Citation Subset: IM |
Affiliation:
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Department of Work Environment, University of Massachusetts, Lowell, MA 01854, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Asthma / diagnosis*, physiopathology Bronchial Provocation Tests Bronchoconstrictor Agents / administration & dosage*, diagnostic use Clinical Protocols Dose-Response Relationship, Drug Female Healthy Worker Effect Humans Industry / manpower* Male Metallurgy / manpower Methacholine Chloride / administration & dosage*, diagnostic use Motor Vehicles Occupational Diseases / diagnosis* United States |
| Grant Support | |
ID/Acronym/Agency:
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M01-RR00125/RR/NCRR NIH HHS; OH00152/OH/NIOSH CDC HHS; R01 OH3457/OH/NIOSH CDC HHS |
| Chemical | |
Reg. No./Substance:
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0/Bronchoconstrictor Agents; 62-51-1/Methacholine Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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