Document Detail

Truncating the dose range for methacholine challenge tests: three occupational studies.
MedLine Citation:
PMID:  12915785     Owner:  NLM     Status:  MEDLINE    
The methacholine challenge test protocol was assessed in the reanalysis of three occupational studies. We evaluated the impact of truncating the range of methacholine on responsiveness, as defined by slope and PC(20). In original analysis, reactivity was similar for apprentices and auto body shop workers, whereas boilermakers were more responsive. Truncating high concentrations did not change the classification of subjects with PC(20) <8 or 16 in any population. However, when responsiveness was measured by slope, the mean responsiveness increased, from -7.9 to -15.3 for apprentices and -7.2 to -10.0 for auto-body shop workers. Results support the American Thoracic Society's recommended maximum of 16 mg/ml and provide evidence that extending the dose range beyond that does not increase sensitivity, whereas stopping before 16 may exaggerate response. Furthermore, to ensure validity, neither slope nor PC(20) should be extrapolated beyond data.
Ilir Agalliu; Ellen A Eisen; Russ Hauser; Carrie A Redlich; Meredith H Stowe; Mark R Cullen; David H Wegman; David C Christiani; Susan M Kennedy
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine     Volume:  45     ISSN:  1076-2752     ISO Abbreviation:  J. Occup. Environ. Med.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-13     Completed Date:  2003-10-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9504688     Medline TA:  J Occup Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  841-7     Citation Subset:  IM    
Department of Work Environment, University of Massachusetts, Lowell, MA 01854, USA.
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MeSH Terms
Asthma / diagnosis*,  physiopathology
Bronchial Provocation Tests
Bronchoconstrictor Agents / administration & dosage*,  diagnostic use
Clinical Protocols
Dose-Response Relationship, Drug
Healthy Worker Effect
Industry / manpower*
Metallurgy / manpower
Methacholine Chloride / administration & dosage*,  diagnostic use
Motor Vehicles
Occupational Diseases / diagnosis*
United States
Grant Support
Reg. No./Substance:
0/Bronchoconstrictor Agents; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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