| Truncated glucagon-like peptide-1 and oxyntomodulin stimulate somatostatin release from rabbit fundic D-cells in primary culture. | |
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MedLine Citation:
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PMID: 8960709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ability of the proglucagon-derived peptides oxyntomodulin and truncated glucagon-like peptide-1 (7-36)amide to stimulate somatostatin release from cultured rabbit fundic D-cells was assessed. Significant stimulation of somatostatin release was seen with both peptides at 10 nM. Potentiation of the stimulatory action of cholecystokinin was seen with both peptides at both 100 pM and 10 nM. The paracrine release of somatostatin from fundic D-cells may explain the acid inhibitory actions of the enteroglucagons. The different small bowel-derived peptides may interact at the level of the D-cell to regulate gastric acid secretion. |
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Authors:
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I L Beales; J Calam |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Experimental physiology Volume: 81 ISSN: 0958-0670 ISO Abbreviation: Exp. Physiol. Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-02-24 Completed Date: 1997-02-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1039-41 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Gastric Acid / secretion Gastric Fundus / cytology, secretion* Glucagon Glucagon-Like Peptide 1 Glucagon-Like Peptides / pharmacology* Oxyntomodulin Peptide Fragments / pharmacology* Rabbits Somatostatin / secretion* |
| Chemical | |
Reg. No./Substance:
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0/Oxyntomodulin; 0/Peptide Fragments; 119637-73-9/glucagon-like peptide 1 (7-36)amide; 51110-01-1/Somatostatin; 62340-29-8/Glucagon-Like Peptides; 89750-14-1/Glucagon-Like Peptide 1; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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