Document Detail

Truncated glucagon-like peptide-1 and oxyntomodulin stimulate somatostatin release from rabbit fundic D-cells in primary culture.
MedLine Citation:
PMID:  8960709     Owner:  NLM     Status:  MEDLINE    
The ability of the proglucagon-derived peptides oxyntomodulin and truncated glucagon-like peptide-1 (7-36)amide to stimulate somatostatin release from cultured rabbit fundic D-cells was assessed. Significant stimulation of somatostatin release was seen with both peptides at 10 nM. Potentiation of the stimulatory action of cholecystokinin was seen with both peptides at both 100 pM and 10 nM. The paracrine release of somatostatin from fundic D-cells may explain the acid inhibitory actions of the enteroglucagons. The different small bowel-derived peptides may interact at the level of the D-cell to regulate gastric acid secretion.
I L Beales; J Calam
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental physiology     Volume:  81     ISSN:  0958-0670     ISO Abbreviation:  Exp. Physiol.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-02-24     Completed Date:  1997-02-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1039-41     Citation Subset:  IM    
Department of Gastroenterology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
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MeSH Terms
Cells, Cultured
Gastric Acid / secretion
Gastric Fundus / cytology,  secretion*
Glucagon-Like Peptide 1
Glucagon-Like Peptides / pharmacology*
Peptide Fragments / pharmacology*
Somatostatin / secretion*
Reg. No./Substance:
0/Oxyntomodulin; 0/Peptide Fragments; 119637-73-9/glucagon-like peptide 1 (7-36)amide; 51110-01-1/Somatostatin; 62340-29-8/Glucagon-Like Peptides; 89750-14-1/Glucagon-Like Peptide 1; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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