Document Detail


Truncated glucagon-like peptide-1 and oxyntomodulin stimulate somatostatin release from rabbit fundic D-cells in primary culture.
MedLine Citation:
PMID:  8960709     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of the proglucagon-derived peptides oxyntomodulin and truncated glucagon-like peptide-1 (7-36)amide to stimulate somatostatin release from cultured rabbit fundic D-cells was assessed. Significant stimulation of somatostatin release was seen with both peptides at 10 nM. Potentiation of the stimulatory action of cholecystokinin was seen with both peptides at both 100 pM and 10 nM. The paracrine release of somatostatin from fundic D-cells may explain the acid inhibitory actions of the enteroglucagons. The different small bowel-derived peptides may interact at the level of the D-cell to regulate gastric acid secretion.
Authors:
I L Beales; J Calam
Related Documents :
7922449 - Dietary bioactive peptides.
8408029 - Endopeptidase from rat liver membranes, which generates miniglucagon from glucagon.
6329549 - Clinical relevance of regulatory gastrointestinal peptides.
2865169 - Isolation and characterization of pross1-32, a peptide derived from the n-terminal regi...
15635659 - Side chain contributions to the interconversion of the topological isomers of guanylin-...
24687309 - Ch-π interaction in vqivyk sequence elucidated by nmr spectroscopy is essential for ph...
15247249 - Regulation of hepatitis c virus polyprotein processing by signal peptidase involves str...
15495159 - Mhc class i-associated presentation of exogenous peptides is not only enhanced but also...
17902199 - Rapid mass spectral identification of contryphans. detection of characteristic peptide ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental physiology     Volume:  81     ISSN:  0958-0670     ISO Abbreviation:  Exp. Physiol.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-02-24     Completed Date:  1997-02-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1039-41     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Gastric Acid / secretion
Gastric Fundus / cytology,  secretion*
Glucagon
Glucagon-Like Peptide 1
Glucagon-Like Peptides / pharmacology*
Oxyntomodulin
Peptide Fragments / pharmacology*
Rabbits
Somatostatin / secretion*
Chemical
Reg. No./Substance:
0/Oxyntomodulin; 0/Peptide Fragments; 119637-73-9/glucagon-like peptide 1 (7-36)amide; 51110-01-1/Somatostatin; 62340-29-8/Glucagon-Like Peptides; 89750-14-1/Glucagon-Like Peptide 1; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Regulation of the adrenocorticotrophin response to stress by the central nucleus of the amygdala in ...
Next Document:  Appearance of the capillary endothelial glycocalyx in chronically stimulated rat skeletal muscles in...