Document Detail

Truncal adiposity is present at birth and in early childhood in South Indian children.
MedLine Citation:
PMID:  15995269     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Muscle-thin but adipose ('thin-fat') body composition of south Asian adults contributes to their high risk of type 2 diabetes. Studies in Pune, India showed that this phenotype is present at birth. We aimed to determine if south Indian babies have a 'thin-fat' phenotype and if this persists in childhood.
DESIGN: Prospective cohort study.
SETTING: Holdsworth Memorial Hospital, Mysore, India.
SUBJECTS: Children (n = 663) whose mothers were recruited from the antenatal clinics.
METHODS: Weight, length, head, mid-upper-arm, abdominal circumferences; triceps and subscapular skinfolds were measured at birth, one and four years, and compared with white Caucasian babies born in Southampton, UK (birth), and UK and Dutch growth standards (one and four years).
RESULTS: Mysore babies were lighter (2983 g vs 3472 g; -1.10 SD, CI -1.16, -1.02) and smaller in all body measurements than UK neonates (P < 0.001). The deficit was greatest for mid-upper-arm (-1.07 SD), head (-0.89 SD) and abdominal circumferences (-0.73 SD), and least for length (-0.25 SD) and subscapular skinfold thickness (-0.19 SD). Predictors of skinfold thickness were maternal body mass index (P < 0.001) and socio-economic status (P = 0.05). At four years, subscapular skinfold thickness was larger than UK (+0.18 SD, CI +0.11, +0.25; P < 0.001) and Dutch standards (+0.61 SD, CI +0.51, +0.71; P < 0.001), despite all other body measurements remaining smaller. Predictors of 4-year skinfold thickness were neonatal skinfold thickness (P = 0.001) and maternal insulin concentrations (P = 0.05).
CONCLUSIONS: Mysore newborns have a 'thin-fat' phenotype. This may reflect the action of genes and/or the 'maternal environment'. The phenotype persists in childhood, and may be the forerunner of a diabetogenic adult phenotype.
G V Krishnaveni; J C Hill; S R Veena; S D Leary; J Saperia; K J Chachyamma; S C Karat; C H D Fall
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian pediatrics     Volume:  42     ISSN:  0019-6061     ISO Abbreviation:  Indian Pediatr     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-07-04     Completed Date:  2006-09-08     Revised Date:  2011-11-18    
Medline Journal Info:
Nlm Unique ID:  2985062R     Medline TA:  Indian Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  527-38     Citation Subset:  IM    
C.S.I. Holdsworth Memorial Hospital, Mandi Mohalla, Mysore 570 021, India.
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MeSH Terms
Adipose Tissue / metabolism*
Child, Preschool
Cross-Cultural Comparison
European Continental Ancestry Group
Great Britain / ethnology
Infant, Newborn
Netherlands / ethnology
Prospective Studies
Skinfold Thickness
Grant Support
059609//Wellcome Trust; //Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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