Document Detail


True hermaphrodite with bilateral ovotestes, bilateral gonadoblastomas and dysgerminomas, 46,XX/46,XY karyotype, and a successful pregnancy.
MedLine Citation:
PMID:  2249209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The first case (to the authors' knowledge) is reported of a true hermaphrodite with bilateral ovotestes, bilateral gonadoblastomas and dysgerminomas, a 46, XX/46,XY karyotype, and a successful pregnancy. The true hermaphroditism was diagnosed during infancy. The patient was subsequently found to have a gonadoblastoma and a microscopic dysgerminoma in the gonad diagnosed as an ovotestis and excised during infancy. The successful pregnancy occurred when the patient was 29 years old. A year later a large gonadal tumor affecting the remaining gonad was excised. The gonad was found to be an ovotestis, and the tumor was a dysgerminoma arising from a gonadoblastoma. This case further emphasizes the malignant potential of the Y chromosome in patients with abnormal gonads.
Authors:
A Talerman; M S Verp; E Senekjian; T Gilewski; N Vogelzang
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer     Volume:  66     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-01-17     Completed Date:  1991-01-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2668-72     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology, University of Chicago, Illinois.
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MeSH Terms
Descriptor/Qualifier:
Dysgerminoma / complications*,  pathology
Female
Gonads / pathology*
Hermaphroditism / complications*,  genetics,  pathology
Humans
Karyotyping
Neoplasms, Multiple Primary / pathology*
Pregnancy*

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