| TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway. | |
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MedLine Citation:
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PMID: 20625999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Altered expression of some members of the TRP ion channel superfamily has been associated with the development of pathologies like cancer. In particular, TRPM4 levels are reportedly elevated in diffuse large B-cell non-Hodgkin lymphoma, prostate, and cervical cancer. However, whether such changes in TRPM4 expression may be relevant to genesis or progression of cancer remains unknown. Here we show that reducing TRPM4 expression decreases proliferation of HeLa cells, a cervical cancer-derived cell line. In this cell line, constitutive TRPM4 silencing promoted GSK-3β-dependent degradation of β-catenin and reduced β-catenin/Tcf/Lef-dependent transcription. Conversely, overexpression of TRPM4 in T-REx 293 cells (a HEK293-derived cell line) increased cell proliferation and β-catenin levels. Our results identify TRPM4 as an important, unanticipated regulator of the β-catenin pathway, where aberrant signaling is frequently associated with cancer. |
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Authors:
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Ricardo Armisén; Katherine Marcelain; Felipe Simon; Julio C Tapia; Jessica Toro; Andrew F G Quest; Andrés Stutzin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cellular physiology Volume: 226 ISSN: 1097-4652 ISO Abbreviation: J. Cell. Physiol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-10-27 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0050222 Medline TA: J Cell Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 103-9 Citation Subset: IM |
Affiliation:
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Centro de Estudios Moleculares de la Célula, Facultad de Medicina, Universidad de Chile, Santiago, Chile. rarmisen@bitmed.med.uchile.cl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Line Cell Proliferation Humans Signal Transduction / physiology* TRPM Cation Channels / genetics, metabolism* Transcription, Genetic Up-Regulation / physiology* beta Catenin / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/TRPM Cation Channels; 0/TRPM4 protein, human; 0/beta Catenin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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