Document Detail

TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway.
MedLine Citation:
PMID:  20625999     Owner:  NLM     Status:  MEDLINE    
Altered expression of some members of the TRP ion channel superfamily has been associated with the development of pathologies like cancer. In particular, TRPM4 levels are reportedly elevated in diffuse large B-cell non-Hodgkin lymphoma, prostate, and cervical cancer. However, whether such changes in TRPM4 expression may be relevant to genesis or progression of cancer remains unknown. Here we show that reducing TRPM4 expression decreases proliferation of HeLa cells, a cervical cancer-derived cell line. In this cell line, constitutive TRPM4 silencing promoted GSK-3β-dependent degradation of β-catenin and reduced β-catenin/Tcf/Lef-dependent transcription. Conversely, overexpression of TRPM4 in T-REx 293 cells (a HEK293-derived cell line) increased cell proliferation and β-catenin levels. Our results identify TRPM4 as an important, unanticipated regulator of the β-catenin pathway, where aberrant signaling is frequently associated with cancer.
Ricardo Armisén; Katherine Marcelain; Felipe Simon; Julio C Tapia; Jessica Toro; Andrew F G Quest; Andrés Stutzin
Related Documents :
2759039 - Activin-a, inhibin and transforming growth factor-beta modulate growth of two gonadal c...
8254819 - Influence of growth factors on in vitro invasiveness and type iv collagenolysis of huma...
20087799 - Aminochrome induces disruption of actin, alpha-, and beta-tubulin cytoskeleton networks...
18640239 - The gk rat beta-cell: a prototype for the diseased human beta-cell in type 2 diabetes?
17386439 - Raman sensitivity enhancement for aqueous absorbing sample using teflon-af 2400 liquid ...
23384419 - Targeting gemcitabine containing liposomes to cd44 expressing pancreatic adenocarcinoma...
19085129 - Dna delivery by microinjection for the generation of recombinant mammalian cell lines.
11960699 - Tgf-beta is required for programmed cell death in interdigital webs of the developing m...
17433909 - Ordered heterogeneity and its decline in cancer and aging.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cellular physiology     Volume:  226     ISSN:  1097-4652     ISO Abbreviation:  J. Cell. Physiol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-10-27     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0050222     Medline TA:  J Cell Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  103-9     Citation Subset:  IM    
Centro de Estudios Moleculares de la Célula, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Line
Cell Proliferation
Signal Transduction / physiology*
TRPM Cation Channels / genetics,  metabolism*
Transcription, Genetic
Up-Regulation / physiology*
beta Catenin / genetics,  metabolism*
Reg. No./Substance:
0/TRPM Cation Channels; 0/TRPM4 protein, human; 0/beta Catenin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Peritoneal dialysate effluent during peritonitis induces human cardiomyocyte apoptosis by regulating...
Next Document:  Adipose tissue-derived progenitors for engineering osteogenic and vasculogenic grafts.