Document Detail


TRPM4 enhances cell proliferation through up-regulation of the β-catenin signaling pathway.
MedLine Citation:
PMID:  20625999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Altered expression of some members of the TRP ion channel superfamily has been associated with the development of pathologies like cancer. In particular, TRPM4 levels are reportedly elevated in diffuse large B-cell non-Hodgkin lymphoma, prostate, and cervical cancer. However, whether such changes in TRPM4 expression may be relevant to genesis or progression of cancer remains unknown. Here we show that reducing TRPM4 expression decreases proliferation of HeLa cells, a cervical cancer-derived cell line. In this cell line, constitutive TRPM4 silencing promoted GSK-3β-dependent degradation of β-catenin and reduced β-catenin/Tcf/Lef-dependent transcription. Conversely, overexpression of TRPM4 in T-REx 293 cells (a HEK293-derived cell line) increased cell proliferation and β-catenin levels. Our results identify TRPM4 as an important, unanticipated regulator of the β-catenin pathway, where aberrant signaling is frequently associated with cancer.
Authors:
Ricardo Armisén; Katherine Marcelain; Felipe Simon; Julio C Tapia; Jessica Toro; Andrew F G Quest; Andrés Stutzin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cellular physiology     Volume:  226     ISSN:  1097-4652     ISO Abbreviation:  J. Cell. Physiol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-10-27     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0050222     Medline TA:  J Cell Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  103-9     Citation Subset:  IM    
Affiliation:
Centro de Estudios Moleculares de la Célula, Facultad de Medicina, Universidad de Chile, Santiago, Chile. rarmisen@bitmed.med.uchile.cl
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MeSH Terms
Descriptor/Qualifier:
Cell Line
Cell Proliferation
Humans
Signal Transduction / physiology*
TRPM Cation Channels / genetics,  metabolism*
Transcription, Genetic
Up-Regulation / physiology*
beta Catenin / genetics,  metabolism*
Chemical
Reg. No./Substance:
0/TRPM Cation Channels; 0/TRPM4 protein, human; 0/beta Catenin

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