Document Detail

Trough Lopinavir Concentrations in Preterm Human Immunodeficiency Virus-Infected Infants.
MedLine Citation:
PMID:  22414907     Owner:  NLM     Status:  Publisher    
Because of serious adverse effects, the Food and Drug Administration warns against using lopinavir (LPV) in infants younger than 42 weeks post conception. However, there is an imperative for early treatment. We report on our use of LPV in 8 premature HIV-infected infants. The median age at initiation was 27days. Trough values guided dosing. Five infants needed doses above 300mg/m. Although no adverse events were noted, LPV usage requires caution and careful monitoring.
Sandi L Holgate; Helena Rabie; Peter Smith; Mark F Cotton
Related Documents :
3099267 - Intravenous immunoglobulin for prevention of sepsis in preterm and low birth weight inf...
7818637 - Neonatal serologic screening and early treatment for congenital toxoplasma gondii infec...
16220097 - Amebiasis in infancy in the middle-high socioeconomic class in istanbul, turkey.
7910277 - Can expression of cd45ro, a t-cell surface molecule, be used to detect congenital infec...
24858107 - The role of the input on the development of the lc bias: a crosslinguistic comparison.
7401187 - Pertussis in infants diagnosed by an ambulatory unit: an illness that still persists.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-12
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  -     ISSN:  1532-0987     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Department of Pediatrics and Child Health, Tygerberg Children's Hospital and Stellenbosch University 2Department of Clinical Pharmacology, Groote Schuur Hospital, University of Cape Town 3Children's Infectious Diseases Research Unit Tygerberg Children's Hospital and Stellenbosch University.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The impact of the H1N1 influenza pandemic on clinical presentations and viral epidemiology of acute ...
Next Document:  Cholesterol efflux assay.