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Trough Lopinavir Concentrations in Preterm Human Immunodeficiency Virus-Infected Infants.
MedLine Citation:
PMID:  22414907     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Because of serious adverse effects, the Food and Drug Administration warns against using lopinavir (LPV) in infants younger than 42 weeks post conception. However, there is an imperative for early treatment. We report on our use of LPV in 8 premature HIV-infected infants. The median age at initiation was 27days. Trough values guided dosing. Five infants needed doses above 300mg/m. Although no adverse events were noted, LPV usage requires caution and careful monitoring.
Authors:
Sandi L Holgate; Helena Rabie; Peter Smith; Mark F Cotton
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-12
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  -     ISSN:  1532-0987     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Department of Pediatrics and Child Health, Tygerberg Children's Hospital and Stellenbosch University 2Department of Clinical Pharmacology, Groote Schuur Hospital, University of Cape Town 3Children's Infectious Diseases Research Unit Tygerberg Children's Hospital and Stellenbosch University.
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