Document Detail


Troponins: redefining their limits.
MedLine Citation:
PMID:  21193685     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The diagnosis of myocardial infarction (MI) depends on a rise and/or fall of cardiac biomarkers such as troponins in the appropriate clinical context. Conventional troponin assays lack sensitivity and precision at the low serum concentrations observed in the early hours after the onset of chest pain. New, highly sensitive troponin assays may offer improved certainty in these early hours. Many of these assays can detect troponins reliably at serum concentrations that occur in patients with chronic stable heart disease and even in asymptomatic healthy individuals. Indiscriminate use of these previously undetectable concentrations for the early diagnosis of acute MI will be accompanied by reduced specificity. However, they are likely to improve risk stratification of patients with chronic heart disease. This review focuses on the available highly sensitive troponin assays and their likely use in the diagnosis of acute MI and risk stratification of patients with heart disease.
Authors:
James O Baker; Johannes Reinhold; Simon Redwood; Michael S Marber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-12-30
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  97     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-22     Completed Date:  2011-04-04     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  447-52     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood
Early Diagnosis
Humans
Myocardial Infarction / diagnosis*
Reference Values
Risk Assessment / methods
Sensitivity and Specificity
Troponin / blood*
Grant Support
ID/Acronym/Agency:
G1000737//Medical Research Council
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Troponin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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