Document Detail


Troponin: messenger or actor?
MedLine Citation:
PMID:  23391193     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiac troponin (cTn) is a biomarker of myocardial damage. New generations of high-sensitivity assays find circulating cTn in virtually all subjects. Multiple studies in various populations and patient groups have found higher levels of cTn to be predictive of future heart failure. The author proposes that initial myocardial damage from various mechanisms may lead to anti-cTn antibodies that participate in ongoing myocardial damage that eventually results in heart failure.
Authors:
Richard L Popp
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  61     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-08     Completed Date:  2013-04-26     Revised Date:  2013-08-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  611-4     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Affiliation:
Cardiovascular Division, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA. rich.popp@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Antibody Formation
Autoantibodies* / immunology,  metabolism
Autoimmunity
Biological Assay
Biological Markers / analysis,  blood
Cardiomyopathies / complications,  immunology,  metabolism
Clinical Laboratory Techniques
Heart Failure / etiology,  immunology,  metabolism
Humans
Immunologic Factors / immunology,  metabolism
Myocardium / metabolism*
Prognosis
Troponin* / blood,  immunology
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Biological Markers; 0/Immunologic Factors; 0/Troponin
Comments/Corrections
Comment In:
J Am Coll Cardiol. 2013 Jun 25;61(25):2571-2   [PMID:  23542109 ]
J Am Coll Cardiol. 2013 Jun 25;61(25):2572   [PMID:  23542108 ]

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