| Troponin I elevation and cardiac events after percutaneous coronary intervention. | |
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MedLine Citation:
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PMID: 12660677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Serum troponins are sensitive markers of myonecrosis and ischemia and are now widely used in clinical practice. Although percutaneous coronary intervention (PCI)-related creatine kinase-myocardial band isoenzyme (CK-MB) elevation has been associated with future cardiac events, the significance of troponin elevation in this setting is unknown. We sought to determine whether serum troponin I (Tn-I) elevation after PCI is associated with future cardiac events. Methods and Results Consecutive patients undergoing elective PCI underwent systematic postprocedure measurement of Tn-I and CK-MB levels. Serum levels were correlated with demographic, angiographic, and procedural characteristics and the development of major adverse cardiac events (MACE; defined as death, MI, or need for PCI or coronary bypass graft surgery) at 30 days, 6 months, and 1 year. In 286 consecutive procedures, postintervention myonecrosis-specific Tn-I was elevated in 13.6% of patients, and CK-MB was elevated in 12.9% of patients. Multivariable predictors of Tn-I elevation were procedural side branch occlusion and thrombus formation. Peak Tn-I and CK-MB values were well correlated (r = 0.81, P <.0001). Three-fold elevation of Tn-I after successful PCI was independently predictive of MACE (P =.01). CONCLUSIONS: Tn-I elevation after elective PCI is relatively common and is associated with procedural complications such as incidental side branch occlusion and thrombus formation. In addition, this study demonstrates that a 3-fold elevation of Tn-I after successful elective PCI is predictive of future cardiac events, especially the need for early repeat revascularization. |
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Authors:
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Mark J Ricciardi; Charles J Davidson; George Gubernikoff; Nirat Beohar; Lorene J Eckman; Michele A Parker; Robert O Bonow |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American heart journal Volume: 145 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-03-27 Completed Date: 2003-06-19 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: 522-8 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiology, Northwestern Memorial Hospital and Northwestern University Medical School, Chicago, Ill 60611, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Angina Pectoris / blood, diagnosis Angioplasty, Balloon, Coronary* / mortality Biological Markers / blood Coronary Angiography Coronary Artery Bypass Coronary Disease / blood, surgery, therapy* Creatine Kinase / blood* Creatine Kinase, MB Form Female Humans Isoenzymes / blood* Male Middle Aged Myocardial Infarction / blood, diagnosis* Myocardial Ischemia / blood, diagnosis Prospective Studies Time Factors Treatment Outcome Troponin T / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Isoenzymes; 0/Troponin T; EC 2.7.3.2/Creatine Kinase; EC 2.7.3.2/Creatine Kinase, MB Form |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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