Document Detail

Troponin-T levels in perinatally asphyxiated infants during the first 15 days of life.
MedLine Citation:
PMID:  16303703     Owner:  NLM     Status:  MEDLINE    
AIM: To measure serial cardiac troponin-T, creatine kinase, creatine kinase-MB, aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase levels in asphyxiated newborn infants during the first 15 d of life. METHODS: Troponin-T, creatine kinase, creatine kinase-MB, aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase (LDH) concentrations were measured prospectively in blood samples obtained from 45 asphyxiated and 15 healthy term neonates within the first 2-4 h, third, seventh and 15th days. RESULTS: Infants with severe asphyxia had significantly higher cardiac troponin-T levels than grade I and II asphyxiated and healthy neonates within the first 2-4 h of life (0.34+/-0.21 ag/ml vs 0.07+/-0.03 ag/ml, 0.12+/-0.07 ag/ml, 0.04+/-0.02 ag/ml, respectively). Troponin-T levels remained high on days 3 and 7 in severely asphyxiated neonates. The creatinine kinase-MB levels were significantly higher in grade II and III asphyxiated neonates than grade I asphyxiated and healthy neonates within the first 2-4 h. No difference was found in creatinine kinase-MB on day 3. There was cardiac involvement in 12 (80%) newborns of group III on B mode echocardiographic images on day 1. However, no echocardigraphic pathology was found in the seventh- and 15th-day echocardiographic analysis in any groups. CONCLUSION: Our results suggest that asphyxia-related cardiac changes were significant but reversible in severely asphyxiated neonates, and troponin T is a good determinant of the degree of injury to the heart within the first week of life. Cardiac troponin T also has a wider diagnostic frame than other diagnostic markers of myocardial damage.
Tamer G?ne?; M Adnan Ozt?rk; Selmin Muradaldi K?kl?; Nazmi Narin; Esad K?kl?
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  94     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-23     Completed Date:  2006-02-23     Revised Date:  2010-03-23    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1638-43     Citation Subset:  IM    
Division of Neonatology, Department of Paediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
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MeSH Terms
Analysis of Variance
Asphyxia Neonatorum / blood*,  enzymology
Biological Markers
Case-Control Studies
Infant, Newborn
Myocardial Ischemia / blood*,  enzymology
Severity of Illness Index
Troponin T / blood*
Reg. No./Substance:
0/Biological Markers; 0/Troponin T

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