| Troponin T level as an exclusion criterion for stem cell transplantation in light-chain amyloidosis. | |
| | |
MedLine Citation:
|
PMID: 18203009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The efficacy of stem cell transplantation in amyloidosis largely is determined by treatment-related mortality rates (range, 11-25%). Appropriate patient selection is essential to avoid this high mortality rate. Among 271 patients undergoing stem cell transplantation, troponin T was a powerful predictor of treatment-related mortality. Patients with troponin T levels of 0.06 microg/L or higher had a day-100 all-cause mortality rate of 28%. Patients with troponin T levels less than 0.06 microg/L had a day-100 all-cause mortality rate of 7% (P < 0.001). Troponin T levels should be measured in all patients before transplantation. Those with troponin T levels exceeding 0.06 microg/L should be considered for less toxic therapies until the clinically optimal use of stem cell transplantation is better defined by randomized clinical trials. |
| | |
Authors:
|
Morie Gertz; Martha Lacy; Angela Dispenzieri; Suzanne Hayman; Shaji Kumar; Francis Buadi; Nelson Leung; Mark Litzow |
Related Documents
:
|
10673669 - Hematopoietic stem cell allografts using a non-myeloablative conditioning regimen can b... 10084769 - Cancers after stem cell transplantation in children: a cost of cure? 19744569 - Low nonrelapse mortality and prolonged long-term survival after reduced-intensity allog... 16860199 - Mesangial proliferative glomerulonephritis after autologous stem cell transplantation. 17919979 - The role of hematopoietic stem cell transplantation in chronic lymphocytic leukemia. 11041569 - Economic analysis of a phase iii study of g-csf vs placebo following allogeneic blood s... 8142239 - Pseudotumor cerebri with vision impairment in two children with renal transplantation. 16263319 - Suicide by severing the arterio-venous subclavian dialysis catheter. 16269589 - Cardiac and extracardiac sympathetic denervation in parkinson's disease with orthostati... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Leukemia & lymphoma Volume: 49 ISSN: 1029-2403 ISO Abbreviation: Leuk. Lymphoma Publication Date: 2008 Jan |
Date Detail:
|
Created Date: 2008-01-18 Completed Date: 2008-04-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: England |
Other Details:
|
Languages: eng Pagination: 36-41 Citation Subset: IM |
Affiliation:
|
Division of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. gertz.morie@mayo.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Amyloidosis / diagnosis*, mortality, therapy* Biological Markers Cause of Death Electrocardiography Female Hematopoietic Stem Cell Transplantation / mortality* Humans Immunoglobulin Light Chains Male Middle Aged Patient Selection* Predictive Value of Tests Prognosis Troponin T / blood* |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Immunoglobulin Light Chains; 0/Troponin T |
| Comments/Corrections | |
Comment In:
|
Leuk Lymphoma. 2008 Jan;49(1):4-5
[PMID:
18203000
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The role of TRAIL death receptors in the treatment of hematological malignancies.
Next Document: DNA ploidy analysis as an adjunct for the detection of relapse in B-lineage acute lymphoblastic leuk...