| Tropomyosin isoforms in nonmuscle cells. | |
| | |
MedLine Citation:
|
PMID: 9002235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Vertebrate nonmuscle cells, such as human and rat fibroblasts, express multiple isoforms of tropomyosin, which are generated from four different genes and a combination of alternative promoter activities and alternative splicing. The amino acid variability among these isoforms is primarily restricted to three alternatively spliced exon regions; an amino-terminal region, an internal exon, and a carboxyl-terminal exon. Recent evidence reveals that these variable exon regions encode amino acid sequences that may dictate isoform-specific functions. The differential expression of tropomyosin isoforms found in cell transformation and cell differentiation, as well as the differential localization of tropomyosin isoforms in some types of culture cells and developing neurons suggest a differential isoform function in vivo. Tropomyosin in striated muscle works together with the troponin complex to regulate muscle contraction in a Ca(2+)-dependent fashion. Both in vitro and in vivo evidence suggest that multiple isoforms of tropomyosin in nonmuscle cells may be required for regulating actin filament stability, intracellular granule movement, cell shape determination, and cytokinesis. Tropomyosin-binding proteins such as caldesmon, tropomodulin, and other unidentified proteins may be required for some of these functions. Strong evidence for the distinct functions carried out by different tropomyosin isoforms has been generated from genetic analysis of yeast and Drosophila tropomyosin mutants. |
| | |
Authors:
|
J J Lin; K S Warren; D D Wamboldt; T Wang; J L Lin |
Related Documents
:
|
16436625 - Smooth muscle of the dorsal aorta shares a common clonal origin with skeletal muscle of... 16361715 - Epithelioid cell histiocytoma with underlying artery damage. 15661645 - Neurom and myod are expressed in separate subpopulations of cells in the pregastrulatin... 8048585 - Role of edrfs in the control of arteriolar diameter during increased metabolism of stri... 6572725 - Prostaglandin biosynthesis by a human macrophage-like cell line, u937. 20504075 - Colonization and osteogenic differentiation of different stem cell sources on electrosp... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: International review of cytology Volume: 170 ISSN: 0074-7696 ISO Abbreviation: Int. Rev. Cytol. Publication Date: 1997 |
Date Detail:
|
Created Date: 1997-02-20 Completed Date: 1997-02-20 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 2985180R Medline TA: Int Rev Cytol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1-38 Citation Subset: IM |
Affiliation:
|
Department of Biological Sciences, University of Iowa, Iowa City 52242-1324, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Fibroblasts / chemistry*, physiology Humans Isoenzymes / chemistry*, physiology Tropomyosin / chemistry*, physiology |
| Grant Support | |
ID/Acronym/Agency:
|
HD 18577/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Isoenzymes; 0/Tropomyosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Regulation of angiogenesis by scatter factor.
Next Document: Pro-opiomelanocortin-derived peptides, cytokines, and nitric oxide in immune responses and stress: a...