Document Detail


Tropomodulin is highly concentrated at the postsynaptic domain of human and rat neuromuscular junctions.
MedLine Citation:
PMID:  8262158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tropomodulin is expressed in skeletal muscle and recent studies suggest that tropomodulin is associated with synaptic membranes. Therefore, we have examined neuromuscular junctions by immunofluorescence analysis for tropomodulin localization. Anti-tropomodulin antibodies generated against either the whole protein or a 15-amino acid peptide fragment label human neuromuscular junctions as demonstrated by colocalization with alpha-bungarotoxin label. Tropomodulin labeling also colocalizes with desmin and beta-amyloid proteins which are concentrated in the postsynaptic region. Comparable results are found with immunostaining of neuromuscular junctions in rat diaphragm muscle. These immunofluorescence results suggest that tropomodulin is an integral component of the cytoskeletal lattice associated with the postsynaptic region of neuromuscular junctions.
Authors:
M A Sussman; M Bilak; L Kedes; W K Engel; V Askanas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental cell research     Volume:  209     ISSN:  0014-4827     ISO Abbreviation:  Exp. Cell Res.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-01-24     Completed Date:  1994-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0373226     Medline TA:  Exp Cell Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  388-91     Citation Subset:  IM    
Affiliation:
Institute for Genetic Medicine, University of Southern California School of Medicine, Los Angeles 90033.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carrier Proteins / metabolism*
Cell Compartmentation
Fluorescent Antibody Technique
Humans
Microfilament Proteins*
Neuromuscular Junction / ultrastructure*
Presynaptic Terminals / ultrastructure*
Rats
Tropomodulin
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Microfilament Proteins; 0/TMOD1 protein, human; 0/Tmod1 protein, rat; 0/Tropomodulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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