Document Detail


Trophoblastic and decidual response to RU486: effects on human chorionic gonadotrophin, human placental lactogen, prolactin and pregnancy-associated plasma protein-A production in vitro.
MedLine Citation:
PMID:  2458379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RU486 [17 beta-hydroxy-11 beta-(4-dimethylaminophenyl)-17 alpha- (prop-1-ynyl)-oestra-4,9-dien-3-one] a potent progesterone antagonist, was shown to induce abortions in humans. Human chorionic gonadotrophin (HCG) and pregnancy-associated plasma protein-A (PAPP-A) decreased after RU486 administration, but it was not clear whether these effects were due to RU486 or secondary to trophoblast damage. To answer this question we tested the in-vitro effects of RU486 on short-term cultures of trophoblastic and decidual explants. It was observed that RU486 induced a significant inhibition of the trophoblastic production rate of beta HCG and PAPP-A but not human placental lactogen. This effect could be overcome by addition of progesterone (for PAPP-A and beta HCG) or cortisol (for beta HCG). Decidual prolactin (Prl) or PAPP-A secretions were also inhibited by RU486. Progesterone antagonized these effects, whereas cortisol was ineffective. These results suggest that PAPP-A is a progesterone-dependent protein and that the abortifacient effect of RU486 in humans could at least partially be due to an inhibition of the production of HCG and/or PAPP-A.
Authors:
P Bischof; M T Sizonenko; W L Herrmann
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  1     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1988-10-20     Completed Date:  1988-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  3-6     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Geneva, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Abortifacient Agents / pharmacology*
Abortifacient Agents, Steroidal / pharmacology*
Chorionic Gonadotropin / biosynthesis
Chorionic Gonadotropin, beta Subunit, Human
Culture Media
Decidua / drug effects*
Estrenes / pharmacology*
Female
Humans
Mifepristone
Peptide Fragments / biosynthesis
Placental Lactogen / biosynthesis
Pregnancy
Pregnancy-Associated Plasma Protein-A / biosynthesis,  secretion
Progestins / antagonists & inhibitors*
Prolactin / biosynthesis,  secretion
Secretory Rate / drug effects
Trophoblasts / drug effects*
Chemical
Reg. No./Substance:
0/Abortifacient Agents; 0/Abortifacient Agents, Steroidal; 0/Chorionic Gonadotropin; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Culture Media; 0/Estrenes; 0/Peptide Fragments; 0/Progestins; 84371-65-3/Mifepristone; 9002-62-4/Prolactin; 9035-54-5/Placental Lactogen; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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