Document Detail

Trophoblast proliferation rate does not predict progression to persistent gestational trophoblastic disease in complete hydatidiform mole.
MedLine Citation:
PMID:  8852444     Owner:  NLM     Status:  MEDLINE    
Persistent gestational trophoblastic disease (PGTD) is a significant complication of complete hydatidiform mole. There are, however, no reliable clinical or pathological parameters to predict the development of PGTD following the evacuation of a complete mole. In this study we examined the value of Ki67 expression in the prediction of PGTD following complete mole. Immunohistochemistry for Ki67 was performed on 21 cases of complete mole complicated by PGTD and 17 cases that resolved spontaneously after evacuation. Strong Ki67 expression was seen in both villous cytotrophoblast and extravillous trophoblast of the complete moles. The Ki67 index of extravillous trophoblast was significantly higher than that of villous cytotrophoblast. There was no significant difference in Ki67 index of either villous cytotrophoblast or extravillous trophoblast between cases of complete mole complicated by PGTD and those that resolved spontaneously. Trophoblast proliferation rate does not predict outcome following complete hydatidiform mole. Other factors involved in myometrial invasion may be of importance in the development of this complication, but serum chorionic gonadotrophin level is the only reliable predictor of the development of persistent gestational trophoblastic disease.
M D Jeffers; J A Richmond; R Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists     Volume:  15     ISSN:  0277-1691     ISO Abbreviation:  Int. J. Gynecol. Pathol.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-12-17     Completed Date:  1996-12-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8214845     Medline TA:  Int J Gynecol Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  34-8     Citation Subset:  IM    
University Department of Pathology, Glasgow Royal Infirmary University NHS Trust, U.K.
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MeSH Terms
Biological Markers
Cell Division*
Chorionic Villi / pathology
Disease Progression*
Hydatidiform Mole / complications,  pathology*
Ki-67 Antigen / biosynthesis
Trophoblastic Neoplasms / pathology*
Trophoblasts / pathology*
Reg. No./Substance:
0/Biological Markers; 0/Ki-67 Antigen

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