| Trophoblast invasion and placentation: molecular mechanisms and regulation. | |
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MedLine Citation:
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PMID: 16129945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Trophoblast invasion is a key process during human placentation. This event constitutes the basis of the conversion of the uterine spiral arteries, a process which allows an adequate vascular connection between the intervillous space and the maternal blood flow. Trophoblast invasion is transient, with stringent spatial and temporal control. Preeclampsia, a leading cause of maternal and fetal mortality and morbidity, is associated with decreased, shallow trophoblastic invasion. In this article, we review the molecular mechanisms of trophoblast invasion, and its mechanisms of regulation. Insights into the etiopathogenesis of preeclampsia will also be detailed. |
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Authors:
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Frédéric van den Brûle; Sarah Berndt; Nadine Simon; Capucine Coulon; Jeanne Le Goarant; Carine Munaut; Agnés Noël; Francis Frankenne; Jean-Michel Foidart |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Chemical immunology and allergy Volume: 88 ISSN: 1660-2242 ISO Abbreviation: Chem Immunol Allergy Publication Date: 2005 |
Date Detail:
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Created Date: 2005-08-30 Completed Date: 2005-11-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101183835 Medline TA: Chem Immunol Allergy Country: Switzerland |
Other Details:
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Languages: eng Pagination: 163-80 Citation Subset: IM |
Affiliation:
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Laboratory of Tumor Biology and Development, Pathology B23, CHU Liege, Liege, Belgium. f.vandenbrule@ulg.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Adhesion Molecules / metabolism Cell Movement* Female Humans Peptide Hydrolases / metabolism Placentation / physiology* Pre-Eclampsia / metabolism, pathology Pregnancy Trophoblasts / cytology*, enzymology, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Cell Adhesion Molecules; EC 3.4.-/Peptide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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