Document Detail

Trophoblast invasion and placentation: molecular mechanisms and regulation.
MedLine Citation:
PMID:  16129945     Owner:  NLM     Status:  MEDLINE    
Trophoblast invasion is a key process during human placentation. This event constitutes the basis of the conversion of the uterine spiral arteries, a process which allows an adequate vascular connection between the intervillous space and the maternal blood flow. Trophoblast invasion is transient, with stringent spatial and temporal control. Preeclampsia, a leading cause of maternal and fetal mortality and morbidity, is associated with decreased, shallow trophoblastic invasion. In this article, we review the molecular mechanisms of trophoblast invasion, and its mechanisms of regulation. Insights into the etiopathogenesis of preeclampsia will also be detailed.
Frédéric van den Brûle; Sarah Berndt; Nadine Simon; Capucine Coulon; Jeanne Le Goarant; Carine Munaut; Agnés Noël; Francis Frankenne; Jean-Michel Foidart
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Chemical immunology and allergy     Volume:  88     ISSN:  1660-2242     ISO Abbreviation:  Chem Immunol Allergy     Publication Date:  2005  
Date Detail:
Created Date:  2005-08-30     Completed Date:  2005-11-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101183835     Medline TA:  Chem Immunol Allergy     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  163-80     Citation Subset:  IM    
Laboratory of Tumor Biology and Development, Pathology B23, CHU Liege, Liege, Belgium.
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MeSH Terms
Cell Adhesion Molecules / metabolism
Cell Movement*
Peptide Hydrolases / metabolism
Placentation / physiology*
Pre-Eclampsia / metabolism,  pathology
Trophoblasts / cytology*,  enzymology,  metabolism*
Reg. No./Substance:
0/Cell Adhesion Molecules; EC 3.4.-/Peptide Hydrolases

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