| Trophic and cytoprotective nutrition for intestinal adaptation, mucosal repair, and barrier function. | |
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MedLine Citation:
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PMID: 12626687 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intestinal epithelial cell turnover (proliferation, migration, differentiation, and apoptosis) and gut barrier functions are dynamic processes that are markedly affected by nutritional status, the route of feeding, and the adequacy of specific nutrients in the diet. Emerging studies are defining potential therapeutic roles for specific nutrients and diet-derived compounds (including arginine, glutamate, glutamine, glutathione, glycine, vitamin A, zinc, and specific lipids) in gut mucosal turnover, repair, adaptation after massive bowel resection, and barrier function. The role and regulation of endogenous bowel flora in generating short-chain fatty acids from diet-derived fiber and other diet-derived compounds and the effects of these agents on gut function are increasingly being elucidated. Results of these investigations should define new nutritional methods for trophic and cytoprotective effects on the intestine in conditions such as inflammatory bowel disease, malnutrition, and short bowel syndrome. |
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Authors:
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Thomas R Ziegler; Mary E Evans; Concepción Fernández-Estívariz; Dean P Jones |
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Publication Detail:
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Type: Journal Article; Review Date: 2003-02-26 |
Journal Detail:
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Title: Annual review of nutrition Volume: 23 ISSN: 0199-9885 ISO Abbreviation: Annu. Rev. Nutr. Publication Date: 2003 |
Date Detail:
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Created Date: 2003-10-06 Completed Date: 2003-11-10 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8209988 Medline TA: Annu Rev Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 229-61 Citation Subset: IM |
Affiliation:
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Department of Medicine, Center for Clinical and Molecular Nutrition, Emory University School of Medicine, Atlanta, Georgia 30322, USA. tzieg01@emory.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Animals Glutamine / therapeutic use Humans Intestinal Diseases / therapy* Intestinal Mucosa / cytology, growth & development, metabolism Intestines / cytology, growth & development, microbiology, physiology* Nutritional Physiological Phenomena* Nutritional Status* Nutritional Support |
| Chemical | |
Reg. No./Substance:
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56-85-9/Glutamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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