Document Detail


Trojan-Horse Nanotube On-Command Intracellular Drug Delivery.
MedLine Citation:
PMID:  23030797     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A major challenge to nanomaterial-based medicine is the ability to release drugs on-command. Here, we describe an innovative drug delivery system based on carbon nanotubes (CNTs), in which compounds can be released inside cells from within the nanotube "on-command" by inductive heating with an external a.c. or pulsed magnetic field. Without inductive heating the drug remains safely inside the CNTs, showing no toxicity in cell viability tests. Similar to the "Trojan-Horse" in function, we demonstrate delivery of a combination of chemotherapeutic agents with low aqueous solubility, paclitaxel (Taxol) and C6-ceramide, to multi-drug resistant pancreatic cancer cells. Nanotube encapsulation permitted the drugs to be used at a 100 fold lower concentration compared to exogenous treatment, yet achieve a comparable ~70% cancer kill rate.
Authors:
Chia-Hsuan Wu; Cong Cao; Jin Ho Kim; Chih-Hsun Hsu; Wayne D Bowen; Harold J Wanebo; Jimmy M Xu; John Marshall
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-3
Journal Detail:
Title:  Nano letters     Volume:  -     ISSN:  1530-6992     ISO Abbreviation:  Nano Lett.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101088070     Medline TA:  Nano Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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