Document Detail


Trojan-horse nanotube on-command intracellular drug delivery.
MedLine Citation:
PMID:  23030797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A major challenge to nanomaterial-based medicine is the ability to release drugs on-command. Here, we describe an innovative drug delivery system based on carbon nanotubes (CNTs), in which compounds can be released inside cells from within the nanotube "on-command" by inductive heating with an external alternating current or pulsed magnetic field. Without inductive heating the drug remains safely inside the CNTs, showing no toxicity in cell viability tests. Similar to the "Trojan-Horse" in function, we demonstrate the delivery of a combination of chemotherapeutic agents with low aqueous solubility, paclitaxel (Taxol), and C6-ceramide, to multidrug resistant pancreatic cancer cells. Nanotube encapsulation permitted the drugs to be used at a 100-fold lower concentration compared to exogenous treatment yet achieve a comparable ~70% cancer kill rate.
Authors:
Chia-Hsuan Wu; Cong Cao; Jin Ho Kim; Chih-Hsun Hsu; Harold J Wanebo; Wayne D Bowen; Jimmy Xu; John Marshall
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-10-25
Journal Detail:
Title:  Nano letters     Volume:  12     ISSN:  1530-6992     ISO Abbreviation:  Nano Lett.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  2013-05-07     Revised Date:  2014-08-06    
Medline Journal Info:
Nlm Unique ID:  101088070     Medline TA:  Nano Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5475-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Combined Chemotherapy Protocols / administration & dosage
Apoptosis
Cell Survival
Ceramides / administration & dosage
Drug Delivery Systems*
Drug Resistance, Neoplasm
Humans
Materials Testing
Nanomedicine / methods
Nanotechnology / methods*
Nanotubes / chemistry*
Paclitaxel / administration & dosage
Pancreatic Neoplasms / drug therapy*
RNA, Small Interfering / metabolism
Solubility
Tetrazolium Salts / pharmacology
Thiazoles / pharmacology
Grant Support
ID/Acronym/Agency:
R21 NS061176/NS/NINDS NIH HHS; R21 NS061176/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Ceramides; 0/RNA, Small Interfering; 0/Tetrazolium Salts; 0/Thiazoles; 038753E78J/N-caproylsphingosine; 298-93-1/thiazolyl blue; 33069-62-4/Paclitaxel
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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