Document Detail

Troglitazone, an antidiabetic drug, improves left ventricular mass and diastolic function in normotensive diabetic patients.
MedLine Citation:
PMID:  11150629     Owner:  NLM     Status:  MEDLINE    
AIMS: Patients with NIDDM have excessive cardiovascular morbidity and mortality, even in the absence of hypertension. Left ventricular hypertrophy (LVH), which is an ominous prognostic sign and an independent risk factor for cardiac events, is often present in NIDDM patients. METHODS AND RESULTS: NIDDM male patients with (n=10) and without (n=12) hypertension, all of whom had been diagnosed over 10 years ago, were examined in the present study. Normotensive NIDDM patients had not received any anti-hypertensive drugs. All patients were classified according to the left ventricular mass (LVM) index by using M-mode echocardiography and were assessed regarding their systolic (fractional shortening) and diastolic function, which included the maximal early flow velocity (MFV), the mitral valve deceleration time (DT), and the isovolumic relaxation time (IRT) as determined by Doppler indices. Troglitazone (TRO), an antidiabetic drug, was administered to both groups at a dose of 400 mg/day for 6 months. After TRO treatment, a reduction in the LVM index and an improvement in the diastolic function were observed in the normotensive but not in the hypertensive patients. CONCLUSION: The TRO treatment was sensitive for cardiac regression in those normotensive patients. These results suggest that LVH and the diastolic function in NIDDM patients without hypertension may be associated with elevated insulin resistance because TRO has a pharmacological function to increase the insulin sensitivity and to decrease insulin resistance.
H Hirayama; M Sugano; N Abe; H Yonemoch; N Makino
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  77     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  75-9     Citation Subset:  IM    
Department of Bioclimatology and Medicine, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara, 874-0838, Beppu, Japan.
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MeSH Terms
Blood Flow Velocity / drug effects
Blood Glucose / metabolism
Blood Pressure / drug effects
Blood Pressure Monitoring, Ambulatory
Chromans / therapeutic use*
Diabetes Mellitus, Type 2 / blood,  complications*,  drug therapy,  physiopathology
Echocardiography, Doppler
Heart Ventricles / drug effects,  physiopathology,  ultrasonography*
Hypertension / complications,  physiopathology,  ultrasonography
Hypertrophy, Left Ventricular / complications,  physiopathology*,  prevention & control
Hypoglycemic Agents / therapeutic use*
Insulin / blood
Middle Aged
Myocardial Contraction / drug effects*
Thiazoles / therapeutic use*
Reg. No./Substance:
0/Blood Glucose; 0/Chromans; 0/Hypoglycemic Agents; 0/Thiazoles; 0/Thiazolidinediones; 11061-68-0/Insulin; 97322-87-7/troglitazone

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