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Tritylamine as an Ammonia Surrogate in the Ugi Tetrazole Synthesis.
MedLine Citation:
PMID:  23331054     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The role of tritylamine is introduced as a convenient ammonia substitute in the Ugi tetrazole synthesis. Fifteen examples and their mild cleavage products are described in satisfactory to good yields. N-Unsubstituted α-aminotetrazoles are important compounds with annotated biological activities, and the described two-step synthesis provided an alternative route to otherwise difficult to access derivatives.
Authors:
Ting Zhao; André Boltjes; Eberhardt Herdtweck; Alexander Dömling
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-18
Journal Detail:
Title:  Organic letters     Volume:  -     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department for Drug Design, University of Groningen , A. Deusinglaan 1, Groningen 9713AV, The Netherlands, and Technische Universität München , Lichtenbergstr. 4, 85747 Garching b. München, Germany.
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