| Tritylamine as an Ammonia Surrogate in the Ugi Tetrazole Synthesis. | |
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MedLine Citation:
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PMID: 23331054 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The role of tritylamine is introduced as a convenient ammonia substitute in the Ugi tetrazole synthesis. Fifteen examples and their mild cleavage products are described in satisfactory to good yields. N-Unsubstituted α-aminotetrazoles are important compounds with annotated biological activities, and the described two-step synthesis provided an alternative route to otherwise difficult to access derivatives. |
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Authors:
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Ting Zhao; André Boltjes; Eberhardt Herdtweck; Alexander Dömling |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-18 |
Journal Detail:
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Title: Organic letters Volume: - ISSN: 1523-7052 ISO Abbreviation: Org. Lett. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department for Drug Design, University of Groningen , A. Deusinglaan 1, Groningen 9713AV, The Netherlands, and Technische Universität München , Lichtenbergstr. 4, 85747 Garching b. München, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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