| Triterpenoid alkaloids from Buxus microphylla. | |
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MedLine Citation:
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PMID: 20658671 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two new triterpenoid alkaloids, buxmicrophyllines J and K (1 and 2, resp.), together with four analogues, 3-6, were isolated from the leaves and stems of Buxus microphylla. The structures of the new compounds were elucidated by NMR and MS spectroscopic analyses. The partial assignments of the NMR spectra of 3 were also revised. Compounds 1 and 3-6 were evaluated for their growth inhibitory activity against human cell lines HL-60, SMMC-7721, A-549, SK-BR-3, and PANC-1. Compound 6 showed significant cytotoxicity against HL-60, SK-BR-3, and PANC-1 cell lines, with IC(50) values of 6.46, 19.61, and 28.57 microM, respectively. |
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Authors:
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Yu-Xin Yan; Jian-Chao Chen; Yun Sun; Yuan-Yuan Wang; Jia Su; Yan Li; Ming-Hua Qiu |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemistry & biodiversity Volume: 7 ISSN: 1612-1880 ISO Abbreviation: Chem. Biodivers. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-11-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101197449 Medline TA: Chem Biodivers Country: Switzerland |
Other Details:
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Languages: eng Pagination: 1822-7 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P. R. China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkaloids
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chemistry*,
isolation & purification,
pharmacology* Antineoplastic Agents, Phytogenic / chemistry*, isolation & purification, pharmacology* Buxus / chemistry* Cell Line, Tumor Cell Survival / drug effects Humans Neoplasms / drug therapy Plant Leaves / chemistry* Triterpenes / chemistry*, isolation & purification, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Alkaloids; 0/Antineoplastic Agents, Phytogenic; 0/Triterpenes; 0/buxmicrophylline J; 0/buxmicrophylline K |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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