| Triterpenes from the Fungus Poria cocos and Their Inhibitory Activity on Nitric Oxide Production in Mouse Macrophages via Blockade of Activating Protein-1 Pathway. | |
| | |
MedLine Citation:
|
PMID: 22083926 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Two new triterpenes, 29-hydroxydehydrotumulosic acid (1) and 29-hydroxydehydropachymic acid (2), together with six known compounds, dehydropachymic acid (3), dehydrotumulosic acid (4), 29-hydroxypolyporenic acid C (5), polyporenic acid C (6), tumulosic acid (7), and pachymic acid (8), were isolated from the dried sclerotia of Poria cocos. In the in vitro bioassays, these isolated compounds reduced, in a dose-dependent manner, nitric oxide (NO) production from lipopolysaccharide (LPS)-induced RAW 264.7 cells, with compounds 5 and 6, the IC(50) values of which were 16.8±2.7 and 18.2±3.3 μM, respectively, exhibiting the greatest inhibition activity. Further Western blot analysis conducted on cells pre-treated with compounds 5 and 6, and luciferase assays on activator protein 1-dependent gene expression revealed that the inhibited NO release was attributed to the reduced expression of iNOs (=inducible NO synthase) enzymes, which might be regulated via the blockade of activator protein-1 signaling pathway. |
| | |
Authors:
|
Tian-Ge Cai; Yu Cai |
Related Documents
:
|
7226146 - Consideration of the evidence for mechanisms of 1,1,2-trichloroethylene metabolism, inc... 2499416 - Modification of the mutagenicity of aflatoxin b1 and n-methyl-n'-nitro-n-nitrosoguanidi... 6885046 - Induction of structural chromosome aberrations and sister chromatid exchanges in human ... 3435606 - Investigation of benzo[a]pyrene-globin adducts. 19071776 - Optimization of phenolic compounds analysis by capillary electrophoresis. 656436 - An essential arginine residue in human prostatic acid phosphatase. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Chemistry & biodiversity Volume: 8 ISSN: 1612-1880 ISO Abbreviation: Chem. Biodivers. Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101197449 Medline TA: Chem Biodivers Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 2135-43 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich. |
Affiliation:
|
School of Life Science, Liaoning University, No. 66 Chongshan Road, Shenyang 110036, P. R. China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Phenolic Derivatives from Ruprechtia polystachya and Their Inhibitory Activities on the Glucose-6-ph...
Next Document: Anticandidal Activity of the Essential Oil of Nepeta transcaucasica Grossh.