| Triterpene Acids from Rose Hip Powder Inhibit Self-antigen- and LPS-induced Cytokine Production and CD4(+) T-cell Proliferation in Human Mononuclear Cell Cultures. | |
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MedLine Citation:
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PMID: 22170858 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A triterpene acid mixture consisting of oleanolic, ursolic and betulinic acid isolated from a standardized rose hip powder (Rosa canina L.) has been shown to inhibit interleukin (IL)-6 release from Mono Mac 6 cells. The present study examined the effects of the triterpene acid mixture on the cytokine production and proliferation of CD4(+) T cells and CD19(+) B cells induced by a self-antigen, human thyroglobulin and by lipopolysaccharide in cultures of normal mononuclear cells. The triterpene acid mixture inhibited the production of tumor necrosis factor-α and IL-6 with estimated IC(50) values in the range 35-56 µg/mL, the Th1 cytokines interferon-γ and IL-2 (IC(50) values 10-20 µg/mL) and the antiinflammatory cytokine IL-10 (IC(50) values 18-21 µg/mL). Moreover, the mixture also inhibited CD4(+) T-cell and CD19(+) B-cell proliferation (IC(50) value 22 and 12 µg/mL, respectively). Together, these data demonstrate that oleanolic, ursolic and betulinic acid are active immunomodulatory constituents of the standardized rose hip powder. However, since the estimated IC(50) values are in the µg/mL range, it is questionable whether the content of the triterpene acids in the standardized rose hip powder, alone, can explain the reported clinical effects. Copyright © 2011 John Wiley & Sons, Ltd. |
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Authors:
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Lasse Saaby; Claus Henrik Nielsen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-14 |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: - ISSN: 1099-1573 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Rheumatology, Institute for Inflammation Research, Copenhagen University Hospital, Copenhagen, Denmark; Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Denmark. las@farma.ku.dk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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