| Trisomy 3 in two paediatric post-transplant lymphomas. | |
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MedLine Citation:
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PMID: 12028022 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Few cytogenetic data are available concerning the chromosomal constitution of post-transplant lymphomas. We report two paediatric cases of trisomy 3, as a primary anomaly, in post-transplant lymphoproliferative disease (PTLD) associated with B immunophenotype. Using cytogenetic analysis and fluorescence in situ hybridization on chromosome preparations, we found trisomy 3 in both patients and an extra X chromosome in one. Clinical, histological and immunophenotypical data are presented. Trisomy 3 has been observed in different types of non-Hodgkin's lymphomas but it is relatively rare in B-cell lymphomas, with the exception of marginal zone lymphoma and mantle cell lymphoma. To our knowledge, trisomy 3 is an uncommon cytogenetic finding in PTLD. Further cytogenetic studies of these lymphoproliferative disorders might contribute to evaluate the role of these chromosomal anomalies in the pathogenesis of this disease. |
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Authors:
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Marta S Gallego; Andrea Bernasconi; María T Dávila; Alejandra Rampazzi; Guillermo Chantada; Guillermo Gallo; Jorge Rossi; Cristina Z Barreiro |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: British journal of haematology Volume: 117 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-05-24 Completed Date: 2002-07-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: England |
Other Details:
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Languages: eng Pagination: 558-62 Citation Subset: IM |
Affiliation:
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Cytogenetics Laboratory, Department of Genetics, Prof. Dr. Juan B. Garrahan Pediatric Hospital, Combate de los Pozos 1881, Buenos Aires C.P 1245, Argentina. msgall@intramed.net.ar |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Chromosomes, Human, Pair 3* Herpesvirus 4, Human / isolation & purification Humans Infant Karyotyping Kidney Transplantation* Liver Transplantation* Lymphoma, B-Cell / genetics*, virology Male Postoperative Complications Trisomy* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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