Document Detail


Trisomy 3 in two paediatric post-transplant lymphomas.
MedLine Citation:
PMID:  12028022     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Few cytogenetic data are available concerning the chromosomal constitution of post-transplant lymphomas. We report two paediatric cases of trisomy 3, as a primary anomaly, in post-transplant lymphoproliferative disease (PTLD) associated with B immunophenotype. Using cytogenetic analysis and fluorescence in situ hybridization on chromosome preparations, we found trisomy 3 in both patients and an extra X chromosome in one. Clinical, histological and immunophenotypical data are presented. Trisomy 3 has been observed in different types of non-Hodgkin's lymphomas but it is relatively rare in B-cell lymphomas, with the exception of marginal zone lymphoma and mantle cell lymphoma. To our knowledge, trisomy 3 is an uncommon cytogenetic finding in PTLD. Further cytogenetic studies of these lymphoproliferative disorders might contribute to evaluate the role of these chromosomal anomalies in the pathogenesis of this disease.
Authors:
Marta S Gallego; Andrea Bernasconi; María T Dávila; Alejandra Rampazzi; Guillermo Chantada; Guillermo Gallo; Jorge Rossi; Cristina Z Barreiro
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  British journal of haematology     Volume:  117     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-05-24     Completed Date:  2002-07-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  558-62     Citation Subset:  IM    
Affiliation:
Cytogenetics Laboratory, Department of Genetics, Prof. Dr. Juan B. Garrahan Pediatric Hospital, Combate de los Pozos 1881, Buenos Aires C.P 1245, Argentina. msgall@intramed.net.ar
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Chromosomes, Human, Pair 3*
Herpesvirus 4, Human / isolation & purification
Humans
Infant
Karyotyping
Kidney Transplantation*
Liver Transplantation*
Lymphoma, B-Cell / genetics*,  virology
Male
Postoperative Complications
Trisomy*

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