Document Detail


Trisomy 20 mosaicism confirmed in a phenotypically normal liveborn.
MedLine Citation:
PMID:  2771888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prenatal diagnosis of trisomy 20 mosaicism in this case was based on cytogenetic analysis of cultured amniotic fluid cells (23/252 cells were trisomy 20 representing cells from each of four primary cultures). The pregnancy continued to term and the mosaicism was confirmed in the phenotypically normal male neonate by analysis of cultured foreskin fibroblasts (7/49 cells + 20) and placental cells 20/20 cells + 20) whereas the peripheral lymphocytes were cytogenetically normal (20/20 cells were 46,XY). This represents the first confirmation of trisomy 20 mosaicism in a phenotypically normal full-term neonate.
Authors:
J P Park; J B Moeschler; E Rawnsley; S Z Berg; D H Wurster-Hill
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  9     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-10-03     Completed Date:  1989-10-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  501-4     Citation Subset:  IM    
Affiliation:
Dartmouth-Hitchcock Medical Center, Hanover, NH 03756.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amniocentesis*
Chromosomes, Human, Pair 20*
Female
Humans
Infant, Newborn*
Male
Mosaicism*
Phenotype
Pregnancy
Trisomy*
Comments/Corrections
Comment In:
Prenat Diagn. 1990 Feb;10(2):136-7   [PMID:  2343024 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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