Document Detail

Trisomy 2 in an acardiac twin in a triplet in-vitro fertilization pregnancy.
MedLine Citation:
PMID:  10325298     Owner:  NLM     Status:  MEDLINE    
A case is reported of twin reversed arterial perfusion (TRAP) sequence in a triamniotic dichorionic triplet pregnancy conceived by in-vitro fertilization which was diagnosed at 25 weeks of gestation by colour Doppler sonography. It highlights the risk of monochorionicity-associated morbidity in multiple pregnancies obtained by assisted conception and stresses the importance of chorionicity determination by early ultrasound examination. Cytogenetic analysis of skin from the acardius showed trisomy 2 in all cells, whereas the karyotype in the monochorionic triplet was normal. This is an example of heterokaryotypic monozygotism where the chromosomal abnormality must have occurred during the early cleavage divisions. Aneuploidy as a possible aetiological factor of TRAP sequence is discussed.
C Chaliha; P Schwarzler; M Booker; M A Battash; Y Ville
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  14     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-07-14     Completed Date:  1999-07-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1378-80     Citation Subset:  IM    
Mayday University Hospital, Croydon, Surrey, UK.
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MeSH Terms
Chromosomes, Human, Pair 2*
Fertilization in Vitro*
Heart Defects, Congenital*
Ultrasonography, Prenatal

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