Document Detail


Trisomy 2: confined placental mosaicism in a fetus with intrauterine growth retardation.
MedLine Citation:
PMID:  9061769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a pregnancy that was monitored due to increased risk for Down syndrome in the triple test, a normal karyotype was found in amniocentesis. Follow-up by serial ultrasound examinations revealed intrauterine growth retardation (IUGR) at 20 weeks of gestation. The parents decided to terminate the pregnancy and the karyotype of the placental fibroblasts was 47,XX,+2. Analysis of polymorphic markers of chromosome 2 demonstrated (a) that trisomy 2 was confined to the placenta (CPM), (b) that the trisomy 2 cell line was a result of a meiotic I error of paternal origin, and (c) that the fetal tissues with a normal karyotype were biparental disomy 2.
Authors:
I Ariel; I Lerer; S Yagel; R Cohen; Z Ben-Neriah; D Abeliovich
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  17     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-05-15     Completed Date:  1997-05-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  180-3     Citation Subset:  IM    
Affiliation:
Department of Pathology, Hadassah University Hospital, Hebrew University Hadassah Medical School, Jerusalem, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amniocentesis
Chorionic Gonadotropin, beta Subunit, Human / blood
Chromosomes, Human, Pair 2*
Estriol / blood
Female
Fetal Growth Retardation / genetics*
Humans
Mosaicism*
Placenta*
Polymorphism, Genetic
Pregnancy
Prenatal Diagnosis*
Trisomy*
Ultrasonography, Prenatal
alpha-Fetoproteins / analysis
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin, beta Subunit, Human; 0/alpha-Fetoproteins; 50-27-1/Estriol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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