| Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms. | |
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MedLine Citation:
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PMID: 22270059 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Covering: 1972 to 2011Triptolide, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has attracted extensive exploration due to its unique structure of a diterpenoid triepoxide and multiple biological activities. This review will focus on the structural modifications, structure-activity relationships, pharmacology, and clinical development of triptolide in the last forty years. |
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Authors:
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Zhao-Li Zhou; Ya-Xi Yang; Jian Ding; Yuan-Chao Li; Ze-Hong Miao |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-23 |
Journal Detail:
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Title: Natural product reports Volume: - ISSN: 1460-4752 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502408 Medline TA: Nat Prod Rep Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203, P.R. China. zhmiao@mail.shcnc.ac.cn. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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