Document Detail


Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms.
MedLine Citation:
PMID:  22270059     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Covering: 1972 to 2011Triptolide, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has attracted extensive exploration due to its unique structure of a diterpenoid triepoxide and multiple biological activities. This review will focus on the structural modifications, structure-activity relationships, pharmacology, and clinical development of triptolide in the last forty years.
Authors:
Zhao-Li Zhou; Ya-Xi Yang; Jian Ding; Yuan-Chao Li; Ze-Hong Miao
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-23
Journal Detail:
Title:  Natural product reports     Volume:  -     ISSN:  1460-4752     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502408     Medline TA:  Nat Prod Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203, P.R. China. zhmiao@mail.shcnc.ac.cn.
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